The neuropathological hallmarks of Alzheimer s disease (AD) are the presence of senile
(neuritic) plaques (NP), neurofibrillary tangles (NFT), synapse loss, and neuronal cell loss …

Effective therapeutic intervention in Alzheimer disease (AD) will be most effective if it is
directed at early events in the pathogenic sequence. The cholinergic deficit may be such an …

The cholinergic hypothesis of Alzheimer's disease (AD) states 1. that cholinergic neurons in
the basal forebrain are severely affected in the course of disease, detectable both …

A profound loss of cortical cholinergic innervation is a nearlyinvariant feature of advanced
Alzheimer's disease (AD). The temporal course of this lesion and its relationship to other …

Severe pathology in Alzheimer's disease (AD) results in marked disruption of cortical
circuitry. Formation of neurofibrillary tangles, neuronal loss, decrease in dendritic extent, and …

Although the neurodegeneration occurring in Alzheimer's disease (AD) affects multiple
neurotransmitters, the cholinergic system has received the greatest attention. Acetylcholine …

Other treatments Peripheral effects of cholinergic drugs Central effects of chohnergic drugs
Behavioural tasks and effects Interpretations of the behavioural effects of cholinergic drugs …

Abstract Background The heterogeneity within Alzheimer's disease (AD) seriously
challenges the development of disease-modifying treatments. We investigated volume of the …

Impairment of cholinergic neurotransmission is a well-established fact in Alzheimer's
disease (AD) but there is controversy about its relevance at the early stages of the disease …

The brain systems mostly affected by Alzheimer's disease (AD) are listed in Table 1 (Rossor
et al., 1982; Bird et al., 1983; Davies, 1979). They include either neuronal populations which …