Among the disciplines of medicine, the study of neurological disorders is particularly
challenging. The fundamental inaccessibility of the human neural types affected by disease …

Human neurodegenerative disorders are among the most difficult to study. In particular, the
inability to readily obtain the faulty cell types most relevant to these diseases has impeded …

The systematic generation of neurons from patients with neurological disorders can provide
important insights into disease pathology, progression and mechanism. This review will …

Reprogramming of somatic cells to an embryonic-like state has dramatically changed the
landscape of stem cell research. Although still in its formative stages, the field of induced …

The number of patients with neurodegenerative diseases is increasing significantly
worldwide. Thus, intense research is being pursued to uncover mechanisms of disease …

Introduction: Although intensive efforts have been made, effective treatments for
neurodegenerative and neurodevelopmental diseases have not been yet discovered …

Many human neurological diseases are not currently curable and result in devastating
neurologic sequelae. The increasing availability of induced pluripotent stem cells (iPSCs) …

The ability to use induced pluripotent stem cells (iPSC) to model brain diseases is a
powerful tool for unraveling mechanistic alterations in these disorders. Rodent models of …

Neurodegenerative diseases represent a growing public health challenge. Current
medications treat symptoms, but none halt or retard neurodegeneration. The recent advent …

Abstract Development of effective therapeutics for neurological disorders has historically
been challenging partly because of lack of accurate model systems in which to investigate …