N-terminal modifications play a major role in the fate of proteins in terms of activity, stability,
or subcellular compartmentalization. Such modifications remain poorly described and badly …

Protein Nα‐terminal acetylation represents one of the most abundant protein modifications
of higher eukaryotes. In humans, six Nα‐acetyltransferases (Nats) are responsible for the …

N-terminal acetylation (NTA) is a prevalent protein modification in eukaryotes. The majority
of proteins are acetylated at their N-terminus in a co-translational manner by ribosome …

Most proteins in all organisms undergo crucial N‐terminal modifications involving N‐
terminal methionine excision, N‐α‐acetylation or N‐myristoylation (N‐Myr), or S …

N-terminal (Nt) acetylation is known to be a highly abundant co-translational protein
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …

N terminal protein α-acetylation (NTA) is a pervasive protein modification that has recently
attracted renewed interest. Early studies on NTA were mostly conducted in yeast and …

Cotranslational protein N‐terminal modifications, including proteolytic maturation such as
initiator methionine excision by methionine aminopeptidases and N‐terminal blocking, occur …

Protein acetylation is a highly frequent protein modification. However, comparatively little is
known about its enzymatic machinery. N‐α‐acetylation (NTA) and ε‐lysine acetylation (KA) …

Highlights•N-terminal acetylation, pyroglutamate formation, N-degrons and proteolysis are
reviewed.•N-terminomics provide comprehensive profiling of modification at protein N …

N-terminal processing of proteins is a process affecting a large part of the eukaryotic
proteome. Although N-terminal processing is an essential process, not many large …