Dissolving polymer microneedles for transdermal delivery of insulin

N Zhang, X Zhou, L Liu, L Zhao, H Xie… - Frontiers in …, 2021 - frontiersin.org
It's of great significance to develop insulin-loaded dissolving microneedles (MNs) which are
fabricated with various methods and materials for transdermal delivery of insulin to …

Formulation of two‐layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice

IC Lee, WM Lin, JC Shu, SW Tsai… - … research Part A, 2017 - Wiley Online Library
Dissolving microneedles (MNs) display high efficiency in delivering poorly permeable drugs
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …

In vitro and in vivo assessment of polymer microneedles for controlled transdermal drug delivery

BZ Chen, M Ashfaq, XP Zhang, JN Zhang… - Journal of Drug …, 2018 - Taylor & Francis
Microneedles (MNs) system for transdermal drug delivery has the potential to improve
therapeutic efficacy, proving an approach that is more convenient and acceptable than …

Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity

S Kim, H Yang, J Eum, Y Ma, SF Lahiji, H Jung - Biomaterials, 2020 - Elsevier
Recently, numerous transdermal drug delivery systems have been developed for safe and
efficient delivery of biopharmaceuticals. Dissolving microneedles (DMNs) are one such drug …

Dissolving microneedle patches for transdermal insulin delivery in diabetic mice: potential for clinical applications

CH Chen, VBH Shyu, CT Chen - Materials, 2018 - mdpi.com
In this study, dissolving polymeric microneedle (MN) patches composed of gelatin and
sodium carboxymethyl cellulose (CMC) were used to localize insulin. Their in vitro skin …

Fabrication of composite microneedles integrated with insulin-loaded CaCO3 microparticles and PVP for transdermal delivery in diabetic rats

D Liu, B Yu, G Jiang, W Yu, Y Zhang, B Xu - Materials Science and …, 2018 - Elsevier
Dissolving microneedles (MNs) display high efficiency, safety and painless in transdermal
delivery for poorly permeable drugs. Here, a dissolving composite MNs prepared from …

Dissolving microneedle rollers for rapid transdermal drug delivery

XP Zhang, BL Zhang, BZ Chen, ZQ Zhao… - Drug Delivery and …, 2022 - Springer
Dissolving microneedle patch (DMNP) is a minimally invasive and painless self-
administration device. However, due to skin deformation, it is difficult to apply it on the large …

Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats

MH Ling, MC Chen - Acta biomaterialia, 2013 - Elsevier
This study presents a dissolving microneedle patch, composed of starch and gelatin, for the
rapid and efficient transdermal delivery of insulin. The microneedles completely dissolve …

Fabrication of novel-shaped microneedles to overcome the disadvantages of solid microneedles for the transdermal delivery of insulin

Y Mizuno, K Takasawa, T Hanada, K Nakamura… - Biomedical …, 2021 - Springer
In this study, we fabricated two different microneedles (MNs)—semi-hollow and bird-bill—to
overcome the limitations of solid and coated MNs, respectively. The two MN arrays were …

Practicality of non-invasive glucagon-loaded dissolving microneedle for life-saving treatment of severe hypoglycemia in a diabetic rat model

X Wang, Y Ma, X Qi, X Ruan, D Cao, F Zhao - International Journal of …, 2023 - Elsevier
The development of dissolving microneedles (DMNs) has brought light to the transdermal
delivery of biomolecules that are released into the skin through the rapid dissolution of the …