Novel strategies for anterior segment ocular drug delivery

K Cholkar, SP Patel, AD Vadlapudi… - Journal of ocular …, 2013 - liebertpub.com
Research advancements in pharmaceutical sciences have led to the development of new
strategies in drug delivery to anterior segment. Designing a new delivery system that can …

How liposomes pave the way for ocular drug delivery after topical administration

N Tasharrofi, M Nourozi, A Marzban - Journal of Drug Delivery Science and …, 2022 - Elsevier
The eye is one of the most specialized organs in the body; one of its flawless functions is
vigorously controlling the foreign materials' entrance to the eye. On the other hand, this …

In vitro and ex vivo models to study drug delivery barriers in the posterior segment of the eye

K Peynshaert, J Devoldere, SC De Smedt… - Advanced drug delivery …, 2018 - Elsevier
Many ocular disorders leading to blindness could benefit from efficient delivery of
therapeutics to the retina. However, despite extensive research into drug delivery vehicles …

Application of nanoparticles in ocular drug delivery systems

N Omerović, E Vranić - Health and technology, 2020 - Springer
Application of a drug in the form of eye drops represents easiest, safest and, at the moment,
the most common non-invasive method of ocular drug application. Other conventional …

Drug delivery challenges and current progress in nanocarrier-based ocular therapeutic system

MH Akhter, I Ahmad, MY Alshahrani, AI Al-Harbi… - Gels, 2022 - mdpi.com
Drug instillation via a topical route is preferred since it is desirable and convenient due to the
noninvasive and easy drug access to different segments of the eye for the treatment of …

Polymeric nanoparticles for ophthalmic drug delivery: an update on research and patenting activity

S HS Boddu - Recent patents on Nanomedicine, 2012 - ingentaconnect.com
Despite intense research efforts; effective delivery of drugs to the eye remains an enormous
challenge. The eye is a unique organ with complex structure and functions. It is protected by …

Liposomes and nanotechnology in drug development: focus on ocular targets

M Honda, T Asai, N Oku, Y Araki… - International journal …, 2013 - Taylor & Francis
Poor drug delivery to lesions in patients' eyes is a major obstacle to the treatment of ocular
diseases. The accessibility of these areas to drugs is highly restricted by the presence of …

Ocular drug delivery: a comprehensive review

S Ahmed, MM Amin, S Sayed - AAPS PharmSciTech, 2023 - Springer
The human eye is a sophisticated organ with distinctive anatomy and physiology that
hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration …

Advanced nanodelivery platforms for topical ophthalmic drug delivery

S Gholizadeh, Z Wang, X Chen, R Dana, N Annabi - Drug discovery today, 2021 - Elsevier
Highlights•Eye drops are applied at high frequency due to unique physio-anatomy of
corneal tissue.•Different types of nanodelivery platforms (medical devices) have been …

Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy

S Swetledge, JP Jung, R Carter, C Sabliov - Journal of nanobiotechnology, 2021 - Springer
Advantages of polymeric nanoparticles as drug delivery systems include controlled release,
enhanced drug stability and bioavailability, and specific tissue targeting. Nanoparticle …