BACKGROUND: P-selectin inhibition with protein therapeutics such as antibodies or soluble
ligands given intravenously can decrease thrombosis in a mouse ligation model of venous …

P-selectin inhibition has been evaluated as a therapeutic for prevention and treatment of
venous thrombosis. In this study, a novel oral small-molecule inhibitor of P-selectin, PSI-421 …

OBJECTIVES: P-selectin inhibition has been found to limit venous thrombosis. We
hypothesize that elevated levels of P-selectin will amplify thrombosis, mediated by …

Inhibition of P-selectin by antibody or selectin antagonist decreases inflammation and
thrombosis. This study evaluates the dose-response relationship using a selectin receptor …

BACKGROUND: Vein wall injury after thrombosis is multifactorial but seems dependent on
thrombus and local thrombotic and inflammatory mechanisms. We hypothesized that …

P-selectin inhibition has been shown to decrease thrombogenesis in multiple animal
species. In this study, we show that a novel oral small-molecule inhibitor of P-selectin, PSI …

Background. This study characterizes venous thrombosis in the mouse and examines the
important role that the adhesion molecules P-selectin and E-selectin and the anti …

Purpose: The purpose of this study was to compare the efficacy of P-selectin inhibition with
standard anticoagulant and thrombolytic therapy in a rodent model of established deep vein …

Venous thromboembolism is a very common and costly health problem worldwide.
Anticoagulant treatment for VTE is imperfect: all have the potential for significant bleeding …

Leukocyte adhesion, transendothelial migration, and stasis are important components in the
pathogenesis of deep vein thrombosis. Anesthetized cats were treated with saline, a …