Abstract Background Cancer-associated fibroblasts (CAFs) are one of the most important
components of tumor stroma and play a key role in modulating tumor growth. However, a …

Aberrant activation of receptor tyrosine kinases (RTKs) and the subsequent metabolic
reprogramming play critical roles in cancer progression. Our previous study has shown that …

The epidermal growth factor receptor (EGFR) is upregulated in numerous human cancers.
Inhibition of EGFR signaling induces autophagy in tumor cells. Here, we report an …

Anoikis acts as a critical barrier to metastasis by inducing cell death upon cancer cell
detachment from the extracellular matrix (ECM), thereby preventing tumor cell dissemination …

Phosphorylation networks intimately regulate mechanisms of response to therapies.
Mapping the phospho-catalytic profile of kinases in cells or tissues remains a challenge …

The mammalian ULK kinase complex is the most upstream component in the
macroautophagy/autophagy signaling pathway. ULK1 and homolog ULK2, the sole …

Overexpression of PTP4A phosphatases are associated with advanced cancers, but their
biological functions are far from fully understood due to limited knowledge about their …

Tracing cancer networks with phosphoproteomics | Nature Biotechnology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited …

Selective autophagy of organelles is critical for cellular differentiation, homeostasis, and
organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but …

ABSTRACT Phosphatidylinositol 3-phosphate (PtdIns3P) is a key player of membrane
trafficking regulation, mostly synthesized by the PIK3C3 lipid kinase. The presence of …