Capsaicin is currently used as a specific pharmacological tool for investigation of functions
of primary afferent C-fibres. Their peripheral terminals play an important role in “neurogenic …

The aim of this study is to elucidate whether the excitatory amino acid glutamate is released
from capsaicin-sensitive primary afferent fibers, and to compare the releasing effect of …

The aim of the present in vivo microdialysis study was to determine the possible contribution
of N-methyl-d-aspartate (NMDA) or α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid …

Capsaicin treatment (50 mglkg, subcutaneous) of newborn rats resulted in a 75% decrease
of substance P immunoreactivity in the dorsal spinal cord of the adult animal, but failed to …

Substance P and glutamate are present in primary afferent C-fibers and play important roles
in persistent inflammatory and neuropathic pain. In the present study, we have examined …

We examined whether capsaicin evokes the release of glutamate from unmyelinated
primary afferent fibers, using a fluorometric on-line monitoring system, in which immobilized …

Increased release of substance P (SP) from the dorsal horn following noxious stimuli, such
as spinal administration of capsaicin, has been demonstrated in previous studies. However …

The relationship between substance P release and the activation of its receptor in the spinal
cord remains unclear. Substance P release is usually measured by radioimmunoassay …

In vitro superfusion release experiments and autoradiography were carried out on spinal
cords of neonatally capsaicin-treated rats. Electrical and chemical stimulations significantly …

The presence of the peptide substance P in small unmyelinated primary sensory neurons 5
appears to be related to the transmission of nociceptive impulses at the level of the spinal …