Glucagon-like peptide 1 in health and disease

A Andersen, A Lund, FK Knop, T Vilsbøll - Nature Reviews …, 2018 - nature.com
In healthy individuals, the incretin hormone glucagon-like peptide 1 (GLP1) potentiates
insulin release and suppresses glucagon secretion in response to the ingestion of nutrients …

Therapeutic strategies based on glucagon-like peptide 1

CF Deacon - Diabetes, 2004 - Am Diabetes Assoc
Glucagon-like peptide (GLP)-1 is an incretin hormone with potent glucose-dependent
insulinotropic and glucagonostatic actions, trophic effects on the pancreatic β-cells, and …

[HTML][HTML] Recent advances in understanding the role of glucagon-like peptide 1

J Reed, SC Bain, V Kanamarlapudi - F1000Research, 2020 - ncbi.nlm.nih.gov
The discovery that glucagon-like peptide 1 (GLP-1) mediates a significant proportion of the
incretin effect during the postprandial period and the subsequent observation that GLP-1 …

GLP‐1: physiological effects and potential therapeutic applications

K Aaboe, T Krarup, S Madsbad… - Diabetes, Obesity and …, 2008 - Wiley Online Library
Glucagon‐like peptide 1 (GLP‐1) is a gut‐derived incretin hormone with the potential to
change diabetes. The physiological effects of GLP‐1 are multiple, and many seem to …

Emerging cardiovascular actions of the incretin hormone glucagon‐like peptide‐1: potential therapeutic benefits beyond glycaemic control?

DJ Grieve, RS Cassidy… - British journal of …, 2009 - Wiley Online Library
Glucagon‐like peptide‐1 (GLP‐1) is an incretin hormone secreted by the small intestine in
response to nutrient ingestion. It has wide‐ranging effects on glucose metabolism, including …

GLP-1 receptor agonists: a clinical perspective on cardiovascular effects

D Mundil, A Cameron-Vendrig… - Diabetes and Vascular …, 2012 - journals.sagepub.com
The active incretin hormone glucagon-like peptide-1 (7-36) amide (GLP-1) is a 30-amino
acid peptide that exerts glucoregulatory and insulinotropic actions by functioning as an …

The ascending GLP-1 road from clinical safety to reduction of cardiovascular complications

DJ Drucker - Diabetes, 2018 - Am Diabetes Assoc
Glucagon-like peptide 1 (GLP-1) was originally identified as a gut-derived incretin hormone
that lowered glycemia through potentiation of glucose-dependent insulin secretion …

The effect of glucagon-like peptide 1 on cardiovascular risk

J Sivertsen, J Rosenmeier, JJ Holst… - Nature Reviews …, 2012 - nature.com
Abstract Glucagon-like peptide 1 (GLP-1) is an incretin hormone responsible for
amplification of insulin secretion when nutrients are given orally, as opposed to …

GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus

JJ Meier - Nature Reviews Endocrinology, 2012 - nature.com
In healthy humans, the incretin glucagon-like peptide 1 (GLP-1) is secreted after eating and
lowers glucose concentrations by augmenting insulin secretion and suppressing glucagon …

[HTML][HTML] Glucagon-like peptide 1 (GLP-1)

TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …