Cytotoxic-T-lymphocyte human papillomavirus type 16 E5 peptide with CpG-oligodeoxynucleotide can eliminate tumor growth in C57BL/6 mice
YF Chen, CW Lin, YP Tsao, SL Chen - Journal of virology, 2004 - Am Soc Microbiol
Previously, we identified human papillomavirus type 16 (HPV-16) E5 as a tumor rejection
antigen that can induce cytotoxic T lymphocytes (CTLs) to protect against tumor growth (DW …
antigen that can induce cytotoxic T lymphocytes (CTLs) to protect against tumor growth (DW …
Development of a DNA vaccine targeting human papillomavirus type 16 oncoprotein E6
Human papillomavirus (HPV), particularly type 16 (HPV-16), is present in more than 99% of
cervical cancers. The HPV oncoproteins E6 and E7 are constantly expressed and therefore …
cervical cancers. The HPV oncoproteins E6 and E7 are constantly expressed and therefore …
Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16
I Melero, MC Singhal, P McGowan, HS Haugen… - Journal of …, 1997 - Am Soc Microbiol
Certain human papillomaviruses (HPV) have been implicated in the etiology of cervical
malignancies, and the E7 and E6 gene products of HPV type 16 are frequently expressed in …
malignancies, and the E7 and E6 gene products of HPV type 16 are frequently expressed in …
Cytotoxic T lymphocytes raised against a subdominant epitope offered as a synthetic peptide eradicate human papillomavirus type 16‐induced tumors
MCW Feltkamp, GR Vreugdenhil… - European journal of …, 1995 - Wiley Online Library
Previously, we have shown that immunization with human papillomavirus (HPV) type 16‐
derived cytotoxic T lymphocyte (CTL) epitope E7 49–57 (RAHYNIVTF) renders C57BL/6 …
derived cytotoxic T lymphocyte (CTL) epitope E7 49–57 (RAHYNIVTF) renders C57BL/6 …
Human papillomavirus type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6 mice
P Ohlschlager, W Osen, K Dell, S Faath… - Journal of …, 2003 - Am Soc Microbiol
We analyzed capsomeres of human papillomavirus type 16 (HPV16) consisting of the L1
major structural protein for their ability to trigger a cytotoxic T-cell (CTL) response. To this …
major structural protein for their ability to trigger a cytotoxic T-cell (CTL) response. To this …
Vaccination with human papillomavirus type 16 E7 peptide with CpG oligonucleotides for prevention of tumor growth in mice
KB Gendron, A Rodriguez… - … of Otolaryngology–Head …, 2006 - jamanetwork.com
Objective To test whether an E7 peptide/CpG vaccine is effective in preventing and treating
human papillomavirus–positive tumors in a murine model. Intervention First, an E7 …
human papillomavirus–positive tumors in a murine model. Intervention First, an E7 …
Identification of a cytotoxic T-lymphocyte epitope in the human papillomavirus type 16 E2 protein
J Konya, C Eklund, V af Geijersstam… - Journal of General …, 1997 - microbiologyresearch.org
Persistent infection with oncogenic types of human papillomaviruses (HPV) is the major
cause of cervical cancer precursor lesions. Cellular immune responses are considered …
cause of cervical cancer precursor lesions. Cellular immune responses are considered …
Targeting human papillomavirus type 16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine human …
DNA vaccination is an attractive approach for tumor immunotherapy because of its stability
and simplicity of delivery. Advances demonstrate that helper T cell responses play a critical …
and simplicity of delivery. Advances demonstrate that helper T cell responses play a critical …
Tumor regression in mice following vaccination with human papillomavirus E7 recombinant protein in PROVAX.
K Hariharan, G Braslawsky… - International …, 1998 - spandidos-publications.com
Induction of CD8+ cytotoxic T lymphocytes (CTLs) specific for human papillomavirus (HPV)
antigens provides an attractive strategy for immunotherapy of HPV-related cancers in …
antigens provides an attractive strategy for immunotherapy of HPV-related cancers in …
A DNA vaccine encoding a codon-optimized human papillomavirus type 16 E6 gene enhances CTL response and anti-tumor activity
CT Lin, YC Tsai, L He, R Calizo, HH Chou… - Journal of biomedical …, 2006 - Springer
The HPV oncoproteins E6 and E7 are consistently expressed in HPV-associated cancer
cells and are responsible for their malignant transformation. Therefore, HPV E6 and E7 are …
cells and are responsible for their malignant transformation. Therefore, HPV E6 and E7 are …