Phospholipase A2 receptor 1 epitope spreading at baseline predicts reduced likelihood of remission of membranous nephropathy

B Seitz-Polski, H Debiec, A Rousseau… - Journal of the …, 2018 - journals.lww.com
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in primary membranous
nephropathy. Several PLA2R1 epitopes have been characterized, and a retrospective study …

Epitope spreading of autoantibody response to PLA2R associates with poor prognosis in membranous nephropathy

B Seitz-Polski, G Dolla, C Payré… - Journal of the …, 2016 - journals.lww.com
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in idiopathic
membranous nephropathy. However, the value of anti-PLA2R1 antibody titers in predicting …

Clinical relevance of domain-specific phospholipase A2 receptor 1 antibody levels in patients with membranous nephropathy

L Reinhard, G Zahner, S Menzel… - Journal of the …, 2020 - journals.lww.com
Background Antibodies against phospholipase A 2 receptor 1 (PLA 2 R1) are found in 80%
of patients with membranous nephropathy, and previous studies described three …

Phospholipase A2 receptor antibodies in membranous nephropathy: unresolved issues

JM Hofstra, JFM Wetzels - Journal of the American Society of …, 2014 - journals.lww.com
The discovery of the M-type phospholipase A2 receptor (PLA2R) as a major antigen in
idiopathic membranous nephropathy (iMN) was a breakthrough and established iMN as an …

[HTML][HTML] Anti-PLA2R1 antibodies as prognostic biomarker in membranous nephropathy

AE van De Logt, J Justino, CH Vink… - Kidney International …, 2021 - Elsevier
Introduction Personalized treatment for patients with membranous nephropathy requires
accurate prediction of the disease course at an early stage. In this study, we evaluated the …

Anti-phospholipase A2 receptor antibody titer predicts post-rituximab outcome of membranous nephropathy

P Ruggenenti, H Debiec, B Ruggiero… - Journal of the …, 2015 - journals.lww.com
Rituximab induces nephrotic syndrome (NS) remission in two-thirds of patients with primary
membranous nephropathy (MN), even after other treatments have failed. To assess the …

Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy

JM Hofstra, H Debiec, CD Short, T Pellé… - Journal of the …, 2012 - journals.lww.com
The phospholipase A 2 receptor (PLA 2 R) is the major target antigen in idiopathic
membranous nephropathy. The technique for measuring antibodies against PLA 2 R and …

[HTML][HTML] Prognostic value of PLA2R autoimmunity detected by measurement of anti-PLA2R antibodies combined with detection of PLA2R antigen in membranous …

F Pourcine, K Dahan, F Mihout, M Cachanado… - PloS one, 2017 - journals.plos.org
Introduction Clinical course of membranous nephropathy (MN) is difficult to predict.
Measurement of circulating anti-PLA2R autoantibodies (PLA2R-Ab) and detection in …

[HTML][HTML] Role of phospholipase A2 receptor 1 antibody level at diagnosis for long-term renal outcome in membranous nephropathy

M Mahmud, HO Pinnschmidt, L Reinhard… - PLoS …, 2019 - journals.plos.org
Background Membranous nephropathy (MN) is an autoimmune disease induced by
circulating antibodies against the podocyte protein phospholipase A2 receptor 1 (PLA2R1 …

Antibodies against M-type phospholipase A2 receptor may predict treatment response and outcome in membranous nephropathy

Z Qu, M Zhang, Z Cui, J Wang, M Wang… - American Journal of …, 2018 - karger.com
Background: Anti-phospholipase A2 receptor (PLA2R) antibodies are specific to the
diagnosis of primary membranous nephropathy (pMN). The prevalence of positive …