Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats

W Yu, J Wu, F Cai, J Xiang, W Zha, D Fan, S Guo… - PloS one, 2012 - journals.plos.org
Objectives Diabetic cardiomyopathy (DCM), characterized by myocardial structural and
functional changes, is an independent cardiomyopathy that develops in diabetic individuals …

Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC–MAPK signaling pathway

V Soetikno, FR Sari, V Sukumaran… - European Journal of …, 2012 - Elsevier
The development of diabetic cardiomyopathy is accompanied with a high membrane-bound
protein kinase C (PKC) levels. Curcumin is a naturally occurring compound which is known …

Curcumin, a polyphenolic curcuminoid with its protective effects and molecular mechanisms in diabetes and diabetic cardiomyopathy

J Zheng, J Cheng, S Zheng, Q Feng… - Frontiers in …, 2018 - frontiersin.org
As the leading cause of morbidity and mortality in patients with diabetes, diabetic
cardiomyopathy (DCM) imposes enormous burden on individuals and public health …

The potential effect of garlic extract and curcumin nanoparticles against complication accompanied with experimentally induced diabetes in rats

AD Abdel-Mageid, MES Abou-Salem, NMHA Salaam… - Phytomedicine, 2018 - Elsevier
Background Modified herbal medicines implicate the combination of several therapeutic
practices of native systems of medicine that may extend many earlier generations, which …

[HTML][HTML] Curcumin augments the cardioprotective effect of metformin in an experimental model of type I diabetes mellitus; Impact of Nrf2/HO-1 and JAK/STAT pathways

EM Abdelsamia, SA Khaleel, A Balah… - Biomedicine & …, 2019 - Elsevier
Metformin is one of the most commonly prescribed antidiabetic drugs. A recent clinical study
has highlighted the protective role of metformin against cardiac complications in type I …

Tetrahydrocurcumin ameliorates diabetic cardiomyopathy by attenuating high glucose‐induced oxidative stress and fibrosis via activating the SIRT1 pathway

K Li, M Zhai, L Jiang, F Song, B Zhang… - Oxidative medicine …, 2019 - Wiley Online Library
Hyperglycemia‐induced oxidative stress and fibrosis play a crucial role in the development
of diabetic cardiomyopathy (DCM). Tetrahydrocurcumin (THC), a major bioactive metabolite …

Curcumin ameliorated myocardial infarction by inhibition of cardiotoxicity in the rat model

M Rahnavard, M Hassanpour, M Ahmadi… - Journal of cellular …, 2019 - Wiley Online Library
Cardiovascular diseases are the main cause of death globally. Many attempts have been
done to ameliorate the pathological changes after the occurrence of myocardial infarction …

Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1‐Foxo1 and PI3K‐Akt signalling pathways

B Ren, Y Zhang, S Liu, X Cheng, X Yang… - Journal of cellular …, 2020 - Wiley Online Library
Diabetes is a disorder of glucose metabolism, and over 90% are type 2 diabetes. Diabetic
cardiomyopathy (DCM) is one of the type 2 diabetes complications, usually accompanied by …

Curcumin improves diabetic cardiomyopathy by inhibiting pyroptosis through AKT/Nrf2/ARE pathway

Z Wei, K Pinfang, Z Jing, Y Zhuoya… - Mediators of …, 2023 - Wiley Online Library
This study is aimed at exploring whether curcumin can regulate the AKT pathway, promote
the transfer of Nrf2 into the nucleus, and inhibit cell pyroptosis in diabetic cardiomyopathy …

[HTML][HTML] Curcumin and cardiovascular diseases: Focus on cellular targets and cascades

AM Pourbagher-Shahri, T Farkhondeh… - Biomedicine & …, 2021 - Elsevier
Cardiovascular diseases (CVDs) are one of the leading causes of the most considerable
mortality globally, and it has been tried to find the molecular mechanisms and design new …