The reaction rate between nitric oxide and intraerythrocytic hemoglobin plays a major role in
nitric oxide bioavailability and modulates homeostatic vascular function. It has previously …

It has been reported that free hemoglobin (Hb) reacts with NO at an extremely high rate (K
Hb∼ 10 7 m− 1 s− 1) and that the red blood cell (RBC) membrane is highly permeable to …

The process of NO transfer into erythrocytes (RBCs) is of critical biological importance
because it regulates the bioavailability and diffusional distance of endothelial-derived NO. It …

Experimental measurements have suggested a consumption rate of nitric oxide (NO) by red
blood cells (RBCs) that is orders of magnitude smaller than that of an equivalent …

Nitric oxide (NO) acts as a smooth muscle relaxation factor and plays a crucial role in
maintaining vascular homeostasis. NO is scavenged rapidly by hemoglobin (Hb). However …

It is generally believed that the erythrocyte membrane is highly permeable to nitric oxide
(NO). To prevent NO from freely entering and being scavenged by the red blood cell (RBC) …

Concentration changes of nitric oxide (NO) were monitored using an NO-sensitive electrode
in phosphate-buffered saline (PBS) with either free oxyhemoglobin (oxyHb) or red blood …

Experimental evidence has shown that nitrite anion plays a key role in one of the proposed
mechanisms for hypoxic vasodilation, in which the erythrocyte acts as a NO generator and …

Allosteric regulation of nitrite reduction by deoxyhemoglobin has been proposed to mediate
nitric oxide (NO) formation during hypoxia. Nitrite is predominantly an anion at physiological …

Recent studies have generated a great deal of interest in a possible role for red blood cells
in the transport of nitric oxide (NO) to the microcirculation and the vascular effect of this nitric …