Genome-wide methylation profiling in granulosa lutein cells of women with polycystic ovary syndrome (PCOS)

E Makrinou, AW Drong, G Christopoulos… - Molecular and cellular …, 2020 - Elsevier
Abstract Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder
amongst women of reproductive age, whose aetiology remains unclear. To improve our …

DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome

P Sagvekar, P Kumar, V Mangoli, S Desai… - Clinical …, 2019 - Springer
Background Women with polycystic ovary syndrome (PCOS) manifest a host of ovarian
defects like impaired folliculogenesis, anovulation, and poor oocyte quality, which grossly …

[HTML][HTML] Genome-wide screen of ovary-specific DNA methylation in polycystic ovary syndrome

YY Yu, CX Sun, YK Liu, Y Li, L Wang, W Zhang - Fertility and sterility, 2015 - Elsevier
Objective To compare genome-wide DNA methylation profiles in ovary tissue from women
with polycystic ovary syndrome (PCOS) and healthy controls. Design Case-control study …

[HTML][HTML] Genome-wide DNA methylation and gene expression patterns provide insight into polycystic ovary syndrome development

XX Wang, JZ Wei, J Jiao, SY Jiang, DH Yu, D Li - Oncotarget, 2014 - ncbi.nlm.nih.gov
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in
women. However, the epigenetic mechanism involved in PCOS progression remains largely …

[HTML][HTML] Comprehensive analysis of genome-wide DNA methylation across human polycystic ovary syndrome ovary granulosa cell

J Xu, X Bao, Z Peng, L Wang, L Du, W Niu, Y Sun - Oncotarget, 2016 - ncbi.nlm.nih.gov
Polycystic ovary syndrome (PCOS) affects approximately 7% of the reproductive-age
women. A growing body of evidence indicated that epigenetic mechanisms contributed to …

LINE1 CpG-DNA hypomethylation in granulosa cells and blood leukocytes is associated with PCOS and related traits

P Sagvekar, V Mangoli, S Desai, A Patil… - The Journal of …, 2017 - academic.oup.com
Context: Altered global DNA methylation is indicative of epigenomic instability concerning
chronic diseases. Investigating its incidence and association with polycystic ovary syndrome …

Characterization of DNA methylation and screening of epigenetic markers in polycystic ovary syndrome

P Cao, W Yang, P Wang, X Li… - Frontiers in cell and …, 2021 - frontiersin.org
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder in
women, which is characterized by androgen excess, ovulation dysfunction, and polycystic …

[HTML][HTML] Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women

S Li, D Zhu, H Duan, A Ren, D Glintborg, M Andersen… - Oncotarget, 2017 - ncbi.nlm.nih.gov
As a universally common endocrinopathy in women of reproductive age, the polycystic
ovarian syndrome is characterized by composite clinical phenotypes reflecting the …

Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis

JX Pan, YJ Tan, FF Wang, NN Hou, YQ Xiang… - Clinical …, 2018 - Springer
Background Polycystic ovary syndrome (PCOS), whose etiology remains uncertain, is a
highly heterogenous and genetically complex endocrine disorder. The aim of this study was …

[HTML][HTML] Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process

NEH Mimouni, I Paiva, AL Barbotin, FE Timzoura… - Cell metabolism, 2021 - cell.com
Polycystic ovary syndrome (PCOS) is the most common reproductive and metabolic disorder
affecting women of reproductive age. PCOS has a strong heritable component, but its …