Porcine cytochrome P450 3A: current status on expression and regulation
MK Rasmussen - Archives of Toxicology, 2020 - Springer
The cytochrome P450s (CYPs) constitute a family of enzymes maintaining vital functions in
the body and are mostly recognized for their significant role in detoxification. Of the CYP …
the body and are mostly recognized for their significant role in detoxification. Of the CYP …
Porcine cytochrome 2A19 and 2E1
V Burkina, MK Rasmussen… - Basic & Clinical …, 2019 - Wiley Online Library
Cytochrome P450 (CYP) is a major group of enzymes, which conduct Phase I metabolism.
Among commonly used animal models, the pig has been suggested as the most suitable …
Among commonly used animal models, the pig has been suggested as the most suitable …
Absolute quantification and modulation of cytochrome P450 3A isoforms in cattle liver
In humans and laboratory animals, knowledge about cytochrome P450 (CYP) regulation
and function is detailed and very extensive. However, CYPs have still been incompletely …
and function is detailed and very extensive. However, CYPs have still been incompletely …
A comprehensive analysis of six forms of cytochrome P450 2C (CYP2C) in pigs
Y Uno, S Morikuni, M Shiraishi, A Asano… - Xenobiotica, 2022 - Taylor & Francis
Pigs are an important species used in drug metabolism studies; however, the cytochromes
P450 (P450s or CYPs) have not been fully investigated in pigs. In this study, pig CYP2C32 …
P450 (P450s or CYPs) have not been fully investigated in pigs. In this study, pig CYP2C32 …
A comprehensive investigation of dog cytochrome P450 3A (CYP3A) reveals a functional role of newly identified CYP3A98 in small intestine
Y Uno, S Jikuya, Y Noda, N Murayama… - Drug Metabolism and …, 2023 - ASPET
Dogs are frequently used in drug metabolism studies, and their important drug-metabolizing
enzymes, including cytochromes P450 (P450), have been analyzed. In humans, CYP3A4 is …
enzymes, including cytochromes P450 (P450), have been analyzed. In humans, CYP3A4 is …
Functional characterization of a first avian cytochrome P450 of the CYP2D subfamily (CYP2D49)
H Cai, J Jiang, Q Yang, Q Chen, Y Deng - PLoS One, 2012 - journals.plos.org
The CYP2D family members are instrumental in the metabolism of 20–25% of commonly
prescribed drugs. Although many CYP2D isoforms have been well characterized in other …
prescribed drugs. Although many CYP2D isoforms have been well characterized in other …
[HTML][HTML] Sp1, Instead of AhR, regulates the basal transcription of porcine CYP1A1 at the proximal promoter
X Xie, J Jiang, W Ye, R Chen, Y Deng… - Frontiers in …, 2018 - frontiersin.org
Pigs are commonly used as an animal model to evaluate the toxic effects of exogenous
compounds. Cytochrome P450 1A1 (CYP1A1) metabolizes numerous exogenous …
compounds. Cytochrome P450 1A1 (CYP1A1) metabolizes numerous exogenous …
Cytochrome P450 2J (CYP2J) Genes in Dogs, Cats, and Pigs Are Expressed and Encode Functional Drug-Metabolizing Enzymes
Y Uno, N Murayama, M Ijiri, H Kawaguchi… - Drug Metabolism and …, 2022 - ASPET
Cytochromes P450 (P450 or CYP) have been identified and analyzed in dogs and pigs,
species that are often used in preclinical drug studies. Moreover, P450s are clinically …
species that are often used in preclinical drug studies. Moreover, P450s are clinically …
Cytochrome P450 2J genes are expressed in dogs, cats, and pigs, and encode functional drug-metabolizing enzymes
Y Uno, N Murayama, M Ijiri, H Kawaguchi… - Drug Metabolism and …, 2022 - ASPET
Cytochrome P450s (P450s) have been identified and analyzed in dogs and pigs, species
that are often used in preclinical drug studies. Moreover, P450s are clinically important for …
that are often used in preclinical drug studies. Moreover, P450s are clinically important for …
Role of Sp1, HNF1α, and PXR in the Basal and Rifampicin Induced Transcriptional Regulation of Porcine Cytochrome P450 3A46
L Dong, Q Chen, X Liu, J Wen, J Jiang… - Drug Metabolism and …, 2015 - ASPET
Cytochrome P450 (CYP) 3A46, one of human CYP3A4 homologs, functions as a key
enzyme in the metabolism of xenobiotics in pigs. However, the regulatory mechanism for the …
enzyme in the metabolism of xenobiotics in pigs. However, the regulatory mechanism for the …