Pancreatic cancer is a complex disease accounting for fibrotic tumors and an aggressive
phenotype. Gemcitabine (GEM) is used as a standard therapy, which develops …

Curcumin (CUR), a naturally occurring polyphenol derived from the root of Curcuma longa,
has showed potent anticancer and cancer prevention activity in a variety of cancers …

Pancreatic ductal adenocarcinoma, as one of the most aggressive cancers, is characterized
by rich desmoplastic stroma that forms a physical barrier for anticancer drugs. To address …

Background The next generation magnetic nanoparticles (MNPs) with theranostic
applications have attracted significant attention and will greatly improve nanomedicine in …

In the current study, the surface of superparamagnetic iron oxide (SPION) was coated with
dextran (DEX), and conjugated with folic acid (FA), to enhance the targeted delivery and …

The problems associated with hydrophobic anticancer drugs are among the most important
challenges to achieve efficient therapeutics for cancer treatment. In this study, PEGylated …

Objective: The aim of the study wasto fabricate curcumin-loaded PLGA-PEG-Fe3O4
nanoparticles and comprise the effects of pure curcumin and curcumin-nanomagnetic …

Gemcitabine is an anticancer drug used in the treatment of different cancer types, including
pancreatic ductal adenocarcinoma. The maximum tolerated dose in humans is restricted by …

Desmoplastic and hypoxic pancreatic cancer microenvironment induces aberrant
expression of miRNAs and hypoxia-inducible factor-1α (HIF-1α) responsible for gemcitabine …

Curcumin is a promising anti-cancer drug, but its applications in cancer therapy are limited,
due to its poor solubility, short half-life and low bioavailability. In this study, curcumin loaded …