Hypoglycemia, a major side effect of intensive glucose-lowering therapy, was recently linked
to increased cardiovascular risk in patients with diabetes. Whether increased circulating free …

Abstract Background and Aim Type 2 diabetes (T2DM) is closely associated with the
development of heart failure, which might be related with impaired substrate metabolism and …

Background—Circulating lipid levels and myocardial lipid content (MyLC) is increased in
type 2 diabetes mellitus. This may cause a state of lipotoxicity that compromises left …

Increased myocardial lipid content (MYCL) recently has been linked to the development of
cardiomyopathy in diabetes. In contrast to steatosis in skeletal muscle and liver, previous …

Short-term caloric restriction increases plasma levels of nonesterified fatty acids (NEFAs)
and is associated with increased myocardial triglyceride (TG) content and decreased …

Background Insulin resistance has been independently related to heart failure. However, the
specific mechanisms of high FFA levels in the pathophysiology of heart failure in insulin …

OBJECTIVE—Diabetes and obesity are associated with increased plasma nonesterified fatty
acid (NEFA) levels, myocardial triglyceride accumulation, and myocardial dysfunction …

This study was designed to determine changes in myocardial contractile function and fuel
selection during moderate coronary hypoperfusion in the presence of elevated plasma free …

Fatty acids in cardiac muscle compete with glucose for oxidation, thereby inhibiting glucose
utilisation. It is not clear whether a similar mechanism is important in resting skeletal muscle …

Objectives: This study was designed to determine if the fatty acid-induced increase in H+
production from glycolysis uncoupled from glucose oxidation delays the recovery of …