Background Cysteine cathepsins are normally found in the lysosomes where they are
involved in intracellular protein turnover. Their ability to degrade the components of the …

Cysteine cathepsins have been for a long time considered to execute mainly nonspecific
bulk proteolysis in the endolysosomal system. However, this view has been changing …

Cysteine cathepsins are lysosomal proteases with housekeeping as well as highly
specialized functions. Although their activities are optimal at lysosomal acidic and reducing …

Cysteine cathepsins participate in extracellular matrix (ECM) degradation and remodelling
and thus influence important cellular processes such as cell transformation and …

For a long time, cysteine cathepsins were considered primarily as proteases crucial for
nonspecific bulk proteolysis in the endolysosomal system. However, this view has …

It is more than 50years since the lysosome was discovered. Since then its hydrolytic
machinery, including proteases and other hydrolases, has been fairly well identified and …

The general view on cysteine cathepsins, which were long believed to be primarily involved
in intracellular protein turnover, has dramatically changed in last 10 to 15 years. The …

Human cysteine proteases of the papain family have been recognized as potential drug
targets for musculoskeletal diseases. Most of the interest is focused on cathepsins S and K …

Since the discovery of the key role of cathepsin K in bone resorption, cysteine cathepsins
have been investigated by pharmaceutical companies as drug targets. The first clinical …

Extracellular matrix (ECM) remodeling is one of the underlying mechanisms in
cardiovascular diseases. Cathepsin cysteine proteases have a central role in ECM …