Our knowledge of the basic mechanisms of hormone action has increased rapidly during the
last few years. This progress has not been limited to basic research, but has also had an …

Recent insight into the mechanism of steroid hormone receptors in human breast cancer has
led to new approaches in treatment strategy. Estrogen receptor (ER) has now replaced …

Progestin, estrogen, androgen, glucocorticoid as well as mineralocorticoid receptors (PR,
ER, AR, GR and MR, respectively) were all evaluated with specific synthetic radioligands …

Hormone receptors are now understood to play a key role in the cancer problem because
they are important molecular con trols of growth and homeostasis in many cells. This …

• Hormone action at the cellular level begins with binding of the hormone to highly specific
protein receptor molecules. Detailed studies of this complex interaction have placed …

A total of 23 malignant ovarian tumors and 5 benign or tumor-like lesions of the ovary had
their estrogen receptor (ER) status, and of these 15 also had their progesterone receptor …

DURING the past five years several laboratories have clearly demonstrated that a certain
proportion of primary and metastatic breast cancers contain specific estrogen-binding …

That certain human cancers might be hormone dependent was suggested in 1836, when
Cooper reported a correlation between breast cancer growth and the menstrual cycle. 1 The …

Publisher Summary The relation between human breast cancer and the endocrine organs,
long suspected and frequently manipulated, lacked a systematic biological basis until the …