OBJECTIVE—Offspring of mothers with type 1 diabetes (OT1DM) demonstrate increased fat
deposition, hyperinsulinemia, and hyperleptinemia in utero. We examined the influence of …

Fatty acid metabolism and oxidation capacity in the placenta, which likely affects the rate
and composition of lipid delivered to the fetus remains poorly understood. Long chain …

Background The prevalence of maternal obesity is rising rapidly worldwide and constitutes a
major obstetric problem, increasing mortality and morbidity in both mother and offspring …

Aim Gestational diabetes mellitus (GDM) is the most common metabolic disorder during
pregnancy. Accumulating studies have reported metabolites that are significantly associated …

Fetal overgrowth in pregnancies complicated by diabetes is the result of an increased
substrate availability which stimulates fetal insulin secretion and fetal growth. However …

Gestational diabetes mellitus (GDM) is associated with obesity in childhood. This suggests
that consequences of in utero exposure to maternal hyperglycemia extend beyond the fetal …

The diabetic pregnancy is characterized by maternal hyperglycaemia and dyslipidaemia,
such that placental trophoblast cells are exposed to both. The objective was to determine the …

Maternal environment during early developmental stages plays a seminal role in the
establishment of adult phenotype. Using a rabbit model, we previously showed that feeding …

Gestational diabetes mellitus (GDM) is a disease of the mother that associates with altered
fetoplacental vascular function. GDM-associated maternal hyperglycaemia result in fetal …

Placental lipid metabolism is likely to be a determinant of placental transfer of fatty acids to
the fetus. Maternal conditions, such as obesity, have now been shown to regulate placental …