BACKGROUND Small airways are defined as those with a diameter≤ 2 mm. 1 1. van der
Wiel E, ten Hacken NH, Postma DS, van den Berge M. Small-airways dysfunction associates …

According to national and international guidelines, achieving and maintaining asthma
control is a major goal of disease management. In closely controlled clinical trials, good …

Background Small airways dysfunction and inflammation contribute significantly to the
clinical impact of asthma, yet conventional methods of assessing airways function in the …

An estimated 300 million people suffer from asthma worldwide, which is a major public
health problem [1]. Asthma is a chronic inflammatory lung disease that affects the entire …

Background Small airways dysfunction (SAD) in asthma is difficult to measure and a gold
standard is lacking. The aim of this study was to develop a simple tool including items of the …

Conclusions Despite the numerous methodological tools to detect SAD, there is still no gold
standard diagnostic method to assess small airways, especially in severe asthma. Further …

Background: The aim of this review is to summarize the current evidence regarding small
airway disease in asthma, focusing on recent advances in small airway pathophysiology …

Background Although small airway disease is a feature of asthma, its association with
relevant asthma outcomes remains unclear. The ATLANTIS study was designed to identify …

Rationale: Although small airway disease (SAD) is a feature of asthma, the association
between SAD and relevant asthma outcomes remains unclear. The Assessment of Small …

Background Small airways dysfunction (SAD) is well recognised in asthma, yet its role in the
severity and control of asthma is unclear. This study aimed to assess which combination of …