Human antibody 2G12 is a broadly neutralizing antibody that exerts its anti-HIV activity by
targeting a novel oligomannose cluster on HIV-1 gp120. It was previously demonstrated that …

Identification of glycan functional epitopes is of paramount importance for rational design of
glycoconjugate vaccines. We recently mapped the structural epitope of the capsular …

No commercial vaccine is yet available against Group A Streptococcus (GAS), major cause
of pharyngitis and impetigo, with a high frequency of serious sequelae in low-and middle …

* Abbreviations in the text.-Abe, abequose; BSA, bovine serum albumin; CRM, cross-
reacting mutant; Ds, degree of substitution; DTx, diphtheria toxin; E., Escherichia; Gal …

Carbohydrates are the basis for many therapeutic and diagnostic strategies, yet the full
potential of glycans in medicine has not been realized. The study of the precise role of …

Carbohydrate epitopes or glycotopes are structurally diverse, occur in a variety of chemical
contexts, and are present on the surfaces of cells in the body and on the surfaces of …

Antibodies to carbohydrate antigens are critical for the study of bacteria, tumors, blood
groups, and cell-cell adhesion interactions; for the analysis of viral, hormone, and toxin …

Poly-β-(1→ 6)-N-acetylglucosamine (PNAG) was first discovered as a major component of
biofilms formed by Staphylococcus aureus and some other staphylococci but later this …

Plant glycans play a central role in vaccinology: they can serve as adjuvants and/or delivery
vehicles or backbones for the synthesis of conjugated vaccines. In addition, genetic …

The development of the first automated oligosaccharide synthesizer, along with new
methods for screening carbohydrate ligand arrays is likely to lead to a rapid acceleration in …