pH‐Activatable Pre‐Nanozyme Mediated H2S Delivery for Endo‐Exogenous Regulation of Oxidative Stress in Acute Kidney Injury

W Jiang, X Hou, Y Qi, Z Wang, Y Liu, XJ Gao… - Advanced …, 2024 - Wiley Online Library
Oxidative stress induced by excess reactive oxygen species (ROS) is a primary pathogenic
cause of acute kidney injury (AKI). Development of an effective antioxidation system to …

Ultrasmall platinum nanozymes as broad-spectrum antioxidants for theranostic application in acute kidney injury

DY Zhang, H Liu, MR Younis, S Lei, C Yang… - Chemical Engineering …, 2021 - Elsevier
Acute kidney injury (AKI) is a common kidney disease with high mortality rate, while
surprisingly, the supportive treatment and renal replacement are the only available clinical …

Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress

HS Choi, AP Mathew, S Uthaman, A Vasukutty… - Journal of …, 2022 - Springer
Background The reactive oxygen species (ROS) and inflammation, a critical contributor to
tissue damage, is well-known to be associated with various disease. The kidney is …

Reactive oxygen/nitrogen species scavenging and inflammatory regulation by renal-targeted bio-inspired rhodium nanozymes for acute kidney injury theranostics

Y Zheng, H Yi, Z Zhan, SS Xue, G Tang, X Yu… - Journal of Colloid and …, 2024 - Elsevier
Acute kidney injury (AKI) results from the rapid deterioration of renal function, which is
mainly treated by transplantation and dialysis, and has a high mortality rate. Inflammation …

Metal-free multifunctional nanozymes mimicking endogenous antioxidant system for acute kidney injury alleviation

J Liu, X Huang, F Zhang, X Luo, W Yu, C Li… - Chemical Engineering …, 2023 - Elsevier
Cellular redox homeostasis is highly dependent on endogenous antioxidant systems,
including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) …

A bimetallic nanozyme coordinated with quercetin for efficient radical scavenging and treatment of acute kidney injury

J Pan, T Wu, L Chen, X Chen, C Zhang, Y Wang, H Li… - Nanoscale, 2024 - pubs.rsc.org
Acute kidney injury (AKI), characterized by tissue inflammation and oxidative damage, is a
common and potentially life-threatening complication in patients. Quercetin, a natural …

Multi-enzyme mimetic ultrasmall iridium nanozymes as reactive oxygen/nitrogen species scavengers for acute kidney injury management

DY Zhang, MR Younis, H Liu, S Lei, Y Wan, J Qu, J Lin… - Biomaterials, 2021 - Elsevier
Acute kidney injury (AKI) is a kind of kidney disease with a high mortality rate, and is
predominantly associated with abundant endogenous reactive oxygen/nitrogen species …

[HTML][HTML] Clinically translatable gold nanozymes with broad spectrum antioxidant and anti-inflammatory activity for alleviating acute kidney injury

DY Zhang, T Tu, MR Younis, KS Zhu, H Liu, S Lei… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Acute kidney injury (AKI) is associated with aberrant generation of oxidative
species and inflammation, leading to high mortality of in-hospitalized patients. Although N …

Mackinawite nanozymes as reactive oxygen species scavengers for acute kidney injury alleviation

Z Xu, Y Zhu, M Xie, K Liu, L Cai, H Wang, D Li… - Journal of …, 2023 - Springer
Background Iron sulfide nanomaterials have been successfully employed as therapeutic
agents for bacterial infection therapy and catalytic-ferroptosis synergistic tumor therapy due …

Natural metal polyphenol nanozyme: free radical scavenging and antioxidation for the treatment of acute kidney injury

H Yuan, F Wang, Z Wang, D Gu, W Huang… - ACS Materials …, 2023 - ACS Publications
Acute kidney injury (AKI) is a severe renal dysfunction syndrome associated with high
morbidity and mortality. Excessive production of reactive oxygen/nitrogen species (RONS) is …