Physiological roles of ghrelin on obesity

T Sato, T Ida, Y Nakamura, Y Shiimura… - Obesity research & …, 2014 - Elsevier
Ghrelin is a stomach hormone that acts as an endogenous ligand of orphan G-protein
coupled receptor. Ghrelin has various physiological functions, such as the stimulation of …

Meal-related ghrelin suppression requires postgastric feedback

DL Williams, DE Cummings, HJ Grill… - Endocrinology, 2003 - academic.oup.com
Plasma ghrelin levels are rapidly suppressed by ingestion or gastric delivery of nutrients.
Given that the majority of circulating ghrelin appears to be of gastric origin, we addressed …

The role of ghrelin in reward-based eating

M Perelló, JM Zigman - Biological psychiatry, 2012 - Elsevier
The peptide hormone ghrelin acts in the central nervous system as a potent orexigenic
signal. Not only is ghrelin recognized as playing an important role in feeding circuits …

Ghrelin and obesity: identifying gaps and dispelling myths. A reappraisal

MC Makris, A Alexandrou, EG Papatsoutsos… - in vivo, 2017 - iv.iiarjournals.org
The etiology of obesity is complex. Environmental and genetic causes have been implicated
in the development of this disease. Ghrelin is a hormone known to stimulate appetite. There …

Ghrelin: a hormone regulating food intake and energy homeostasis

M Gil-Campos, CM Aguilera, R Canete… - British Journal of …, 2006 - cambridge.org
Regulation of energy homeostasis requires precise coordination between peripheral
nutrient-sensing molecules and central regulatory networks. Ghrelin is a twenty-eight-amino …

[HTML][HTML] Absence of ghrelin protects against early-onset obesity

KE Wortley, JP del Rincon, JD Murray… - The Journal of …, 2005 - Am Soc Clin Investig
The gut peptide ghrelin, the endogenous ligand for the growth hormone secretagogue
receptor, has been implicated not only in the regulation of pituitary growth hormone (GH) …

Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations

HM Lee, G Wang, EW Englander, M Kojima… - …, 2002 - academic.oup.com
Ghrelin, an endogenous ligand for the GH secretagogue receptor was characterized
recently from extracts of rat stomach. We describe the enteric distribution of ghrelin …

Insulin is required for prandial ghrelin suppression in humans

G Murdolo, P Lucidi, C Di Loreto, N Parlanti… - Diabetes, 2003 - Am Diabetes Assoc
Accumulating evidence indicates that ghrelin plays a role in regulating food intake and
energy homeostasis. In normal subjects, circulating ghrelin concentrations decrease after …

[HTML][HTML] From belly to brain: targeting the ghrelin receptor in appetite and food intake regulation

K Howick, BT Griffin, JF Cryan… - International journal of …, 2017 - mdpi.com
Ghrelin is the only known peripherally-derived orexigenic hormone, increasing appetite and
subsequent food intake. The ghrelinergic system has therefore received considerable …

Ghrelin: update on a novel hormonal system

M Korbonits, AB Grossman - European journal of endocrinology, 2004 - academic.oup.com
Ghrelin is a peptide hormone secreted into the circulation from the stomach but also
synthesised in a number of tissues, suggesting both endocrine and paracrine effects. These …