[HTML][HTML] The therapeutic landscape of rheumatoid arthritis: current state and future directions

S Shams, JM Martinez, JRD Dawson, J Flores… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical,
emotional and socioeconomic consequences. Despite advances in targeted biologic and …

Current understanding of rheumatoid arthritis therapy

I Colmegna, BR Ohata… - Clinical Pharmacology & …, 2012 - Wiley Online Library
Progress in understanding the cellular and molecular mechanisms of rheumatoid arthritis
(RA), together with the availability of new therapies, has changed the way we think about …

[HTML][HTML] Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Treatment of rheumatoid arthritis: unraveling the conundrum

E Zampeli, PG Vlachoyiannopoulos, AG Tzioufas - Journal of autoimmunity, 2015 - Elsevier
Rheumatoid arthritis (RA) is a heterogeneous disease with a complex and yet not fully
understood pathophysiology, where numerous different cell-types contribute to a destructive …

[HTML][HTML] Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies

AL Mueller, Z Payandeh, N Mohammadkhani… - Cells, 2021 - mdpi.com
Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

[HTML][HTML] Promising therapeutic targets for treatment of rheumatoid arthritis

J Huang, X Fu, X Chen, Z Li, Y Huang… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …

Novel immunotherapeutic avenues for rheumatoid arthritis

L Semerano, E Minichiello, N Bessis… - Trends in Molecular …, 2016 - cell.com
Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease. It leads to
irreversible joint damage, physical handicap, and reduced life expectancy. The past two …

[HTML][HTML] Advances in the treatment of rheumatoid arthritis

N Vivar, RF Van Vollenhoven - F1000prime reports, 2014 - ncbi.nlm.nih.gov
The intense pursuit of novel therapies in rheumatoid arthritis has provided physicians with
an assorted set of biologic drugs to treat patients with moderate to severe disease activity …

[HTML][HTML] Management of rheumatoid arthritis: an overview

AF Radu, SG Bungau - Cells, 2021 - mdpi.com
Rheumatoid arthritis (RA) is a multifactorial autoimmune disease of unknown etiology,
primarily affecting the joints, then extra-articular manifestations can occur. Due to its …

[HTML][HTML] Immunopathogenic mechanisms and novel immune-modulated therapies in rheumatoid arthritis

SJ Chen, GJ Lin, JW Chen, KC Wang, CH Tien… - International Journal of …, 2019 - mdpi.com
Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown
etiology. It is characterized by the presence of rheumatoid factor and anticitrullinated peptide …