A preclinical model of chronic alcohol consumption reveals increased metastatic seeding of colon cancer cells in the liver

HJ Im, HG Kim, JS Lee, HS Kim, JH Cho, IJ Jo, SJ Park… - Cancer Research, 2016 - AACR
Liver metastasis is the main cause of death from colorectal cancer. Alcohol consumption
impacts liver function and is suggested to be an independent risk factor for liver metastasis …

Enhanced colorectal cancer metastases in the alcohol-injured liver

AM Mohr, JJ Gould, JL Kubik, GA Talmon… - Clinical & experimental …, 2017 - Springer
Metastatic liver disease is a major cause of mortality in colorectal cancer (CRC) patients.
Alcohol consumption is a noted risk factor for secondary cancers yet the role of alcoholic …

Alcohol Use and the risk of colorectal liver Metastasis: a systematic mapping review

R Sapkota, J Zakaria, E Glenn, H Richard, A Rimawi… - Biology, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the third most diagnosed cancer worldwide
and the second leading cause of death in the United States. Many deaths associated with …

[HTML][HTML] Alcohol remodels the immunosuppressive tumor microenvironment by targeting myeloid-derived suppressor cells

X Li, X Deng, X Luo, J Zhong, H Wu… - American Journal of …, 2023 - ncbi.nlm.nih.gov
The tumor immunosuppressive microenvironment plays an important role in tumor
progression. Alcohol is well-known as a regulator of the immune system and several studies …

Alcohol consumption enhances liver metastasis in colorectal carcinoma patients

M Maeda, H Nagawa, T Maeda… - … Journal of the …, 1998 - Wiley Online Library
BACKGROUND It is important to identify risk factors for liver metastasis in patients with
colorectal carcinoma because the liver is the most common site of recurrence. Alcohol …

Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma

F Wang, JL Yang, K Yu, M Xu, Y Xu, L Chen, Y Lu… - Molecular cancer, 2015 - Springer
Background Hepatocellular carcinoma (HCC), the most common form of primary liver
cancer, is the third leading cause of cancer-related death in human. Alcohol is a known risk …

Chronic alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis via immune disturbances

G Yan, X Wang, C Sun, X Zheng, H Wei, Z Tian… - Scientific reports, 2017 - nature.com
Chronic alcohol consumption increases the risk of hepatocellular carcinoma (HCC).
However, little is known about the potential immunological mechanisms by which ethanol …

Alcohol consumption promotes colorectal carcinoma metastasis via a CCL5-induced and AMPK-pathway-mediated activation of autophagy

H Zhao, D Chen, R Cao, S Wang, D Yu, Y Liu… - Scientific reports, 2018 - nature.com
There is a definite relationship between alcohol consumption and colorectal cancer (CRC)
development. We investigated effect of alcohol consumption on CRC patients' progression …

Ethanol promotes alcohol-related colorectal cancer metastasis via the TGF-β/RUNX3/Snail axis by inducing TGF-β1 upregulation and RUNX3 cytoplasmic …

K Zheng, J Yu, Z Chen, R Zhou, C Lin, Y Zhang… - …, 2019 - thelancet.com
Background Alcohol intake is a well-known lifestyle risk factor for CRC, and an increasing
number of studies have revealed that alcohol intake is also tightly associated with CRC …

Alcohol reshapes a liver premetastatic niche for cancer by extra-and intrahepatic crosstalk-mediated immune evasion

X Qiu, J Zhou, H Xu, Y Li, S Ma, H Qiao, K Zeng… - Molecular Therapy, 2023 - cell.com
Cancer metastatic organotropism is still a mystery. The liver is known to be susceptible to
cancer metastasis and alcoholic injury. However, it is unclear whether and how alcohol …