Increased galanin receptor occupancy in Alzheimer's disease

PJ McMillan, E Peskind, MA Raskind, JB Leverenz - Neurobiology of aging, 2004 - Elsevier
Increased galanin (GAL) may be associated with the cognitive deficits characteristic of
Alzheimer's disease (AD). However, both increased and decreased GAL receptor density …

Galanin receptor over-expression within the amygdala in early Alzheimer's disease:: An in vitro autoradiographic analysis

S Pérez, M Basile, DC Mash, EJ Mufson - Journal of chemical …, 2002 - Elsevier
Galanin receptor (GALR) expression is increased in various areas of the limbic system in
end stage Alzheimer's disease (AD). The amygdaloid complex is a key component of the …

Galanin: neurobiologic mechanisms and therapeutic potential for Alzheimer's disease

SE Counts, SE Perez, U Kahl, T Bartfai… - CNS Drug …, 2001 - Wiley Online Library
The neuropeptide galanin (GAL) is widely distributed in the mammalian CNS. Several lines
of evidence suggest that GAL may play a critical role in cognitive processes such as memory …

[HTML][HTML] Galanin in Alzheimer disease

SE Counts, SE Perez, SD Ginsberg… - Molecular …, 2003 - triggered.edina.clockss.org
Galanin (GAL) and GAL receptors (GALR) are overexpressed in limbic brain regions
associated with cognition in Alzheimer disease (AD). The functional consequences of this …

Galanin receptor binding sites in the temporal and occipital cortex are minimally affected in Alzheimer's disease

M Ikeda, D Dewar, J McCulloch - Neuroscience letters, 1995 - Elsevier
Galanin receptor binding sites were examined in the inferior temporal and medial occipital
gyri of patients with Alzheimer's disease (AD) and matched control subjects using …

Neuroprotective role for galanin in Alzheimer's disease

SE Counts, SE Perez, SD Ginsberg, EJ Mufson - Galanin, 2010 - Springer
Galanin (GAL) and GAL receptors (GALR) are overexpressed in degenerating brain regions
associated with cognitive decline in Alzheimer's disease (AD). The functional consequences …

Galanin–25 years with a multitalented neuropeptide: Galanin in Alzheimer's disease: Neuroinhibitory or neuroprotective?

SE Counts, SE Perez, EJ Mufson - Cellular and Molecular Life Sciences, 2008 - Springer
Galanin (GAL) and GAL receptors (GALRs) are overexpressed in degenerating brain
regions associated with cognitive decline in Alzheimer's disease (AD). The functional …

Preservation of noradrenergic neurons in the locus ceruleus that coexpress galanin mRNA in Alzheimer's disease.

MA Miller, PE Kolb, JB Leverenz… - Journal of …, 1999 - search.ebscohost.com
Abstract: Galanin (GAL) innervation is hypertrophied in the basal forebrain and cortex of
patients with Alzheimer's disease (AD). Increased GAL could exacerbate the cognitive and …

Galanin receptor plasticity within the nucleus basalis in early and late Alzheimer's disease: an in vitro autoradiographic analysis

EJ Mufson, DC Deecher, M Basile, S Izenwasse… - …, 2000 - Elsevier
Hypertrophy of fibers containing galanin (GAL), the inhibitory neurotransmitter of
acetylcholine, occur on remaining cholinergic nucleus basalis neurons in late stage …

Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease

RA Steiner, JG Hohmann, A Holmes… - Proceedings of the …, 2001 - National Acad Sciences
Galanin is a neuropeptide with multiple inhibitory actions on neurotransmission and
memory. In Alzheimer's disease (AD), increased galanin-containing fibers hyperinnervate …