Aim Preclinical work indicates that low-density lipoprotein cholesterol (LDL-C) not only
drives atherosclerosis by directing the innate immune response at plaque level but also …

Modulation of hematopoietic stem and progenitor cells (HSPCs) determines immune cell
function. In this study, we investigated how hypercholesterolemia affects HSPC biology and …

Background Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim
Lineage-hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells …

Monocytes play a key role in cardiovascular disease (CVD) as their influx into the vessel
wall is necessary for the development of an atherosclerotic plaque. Monocytes are, however …

Atherosclerotic cardiovascular disease is a chronic inflammatory disease of the blood
vessels that can lead to myocardial infarction or stroke. The major cell in the atherosclerotic …

Rationale: Proinflammatory adaptive immune responses are recognized as major drivers of
atherosclerotic lesion formation. Although CD8+ T cells have recently been proposed as a …

As the pathological basis of cardiovascular disease (CVD), atherosclerosis is featured as a
chronic inflammation. Hypercholesterolemia is an independent risk factor for CVD …

Background and aims Atherogenesis is dependent upon monocyte influx into the vessel
wall. In humans, three monocyte subsets exist, the number and function of which are …

Monocytes are frequently described as bone marrow-derived precursors of macrophages.
Although many studies support this view, we now appreciate that monocytes neither develop …

Atherosclerosis is the major cause of cardiovascular disease (CVD). Monocyte-derived
macrophages are the most abundant immune cells in atherosclerotic plaques. In patients …