SIR-Fore and hind limbs of landdwelling vertebrates have very similar structures despite
having been independently derived from different fins of fish. We suggest that Hox genes …

and partly on the observation that Hox gene expression in the hind limb bud resembles
more closely that of the adjacent trunk mesoderm than does that of the fore limb bud1· 3; …

As well as their shared role in the anteroposterior patterning of vertebrates, particular Hox
gene com-plexes have evolved specific functions. For example, four consecutive genes of …

HOX genes are essential for growth and patterning of the tetrapod limb skeleton1–5. Mice
mutant for the Hoxd-13 gene have an important delay in morphogenesis owing to reduced …

Comparative analyses of Hox gene expression and regulation in teleost fish and tetrapods
support the long-entrenched notion that the distal region of tetrapod limbs, containing the …

CRUSTACEANS and insects share a common origin of segmentation1, 2, but the
specialization of trunk segments appears to have arisen independently in insects and …

Vertebrate Hox genes are well known for their important functions during embryonic
development. They are necessary for the proper organization of a variety of structures, both …

The comparison of Hox genes between vertebrates and their closest invertebrate relatives
(amphioxus and ascidia) highlights two derived features of Hox genes in vertebrates …

Abstract Development of paired appendages at appropriate levels along the primary body
axis is a hallmark of the body plan of jawed vertebrates. Hox genes are good candidates for …

The Hox genes encode a class of transcription factors that are thought to be crucial for
specification of body plans. This means that they are of interest to both developmental and …