Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage
is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its …

Understanding the molecular drivers and feedback loops of osteoarthritis (OA) may provide
future therapeutic strategies to modulate the disease progression. The current paradigm of …

It is increasingly recognized that the pathogenesis of cartilage degradation in osteoarthritis
(OA) is multifactorial and involves the interactions between cartilage and its surrounding …

As the cellular component of articular cartilage, chondrocytes are responsible for
maintaining in a low-turnover state the unique composition and organization of the matrix …

Objectives As more has become known of the pathophysiology of osteoarthritis (OA),
evidence that inflammation plays a critical role in its development and progression has …

Although cartilage degeneration characterizes human osteoarthritis (OA), changes also
involve the participation of the synovial membrane and the subchondral bone. In this review …

Arthritis is inflammation of the joints accompanied by osteochondral destruction. It can take
many forms, including osteoarthritis, rheumatoid arthritis, and psoriatic arthritis. These …

Destruction and loss of articular cartilage is a central feature in most forms of arthritis
including the most common form, osteoarthritis (OA). The pathobiologic differences among …

Osteoarthritis (OA) is a degenerative joint disease that progressively causes loss of joint
function and is the leading source of physical disability and impaired quality of life in …

In osteoarthritis (OA), adult articular chondrocytes undergo phenotypic modulation in
response to alterations in the environment owing to mechanical injury and inflammation …