ADAM19, an enzyme from the ADAM (ad isintegrin and metalloproteinase) family, is
involved in various cell–cell and cell–matrix interactions. It can cleave epidermal growth …

A disintegrin and metalloproteinase (ADAM) 17 sheds growth factors from the cell
membrane, including epidermal growth factor receptor (EGFR) ligand transforming growth …

A disintegrin and metalloproteinases (ADAMs) are a Zn2+-dependent transmembrane and
secreted metalloprotease superfamily, so-called “molecular scissors,” and they consist of an …

It is known that the renin-angiotensin system plays a major role in the pathophysiology of
cardiovascular disease and renal injury. Within the renin-angiotensin system, angiotensin …

Background. Interstitial fibrosis and tubular atrophy (IF/TA) is an important cause of renal
function loss and ischaemia–reperfusion (I/R) injury is considered to play an important role …

Background The importance of the Notch signaling in the development of glomerular
diseases has been recently described. Therefore we analyzed in podocytes the expression …

Acute and chronic kidney lesions induce an increase in A Disintegrin And Metalloproteinase
domain 17 (ADAM17) that cleaves several transmembrane proteins related to inflammatory …

Besides its involvement in blood and bone physiology, the kidney's main function is to filter
substances and thereby regulate the electrolyte composition of body fluids, acid-base …

ADAM19 (a disintegrin and metalloproteinase 19) is involved in cell–cell and cell-matrix
interactions and tumor necrosis factor (TNF)-alpha shedding. We studied ADAM19 in …

Background The disintegrin and metalloenzyme ADAM17 participates in numerous
inflammatory and proliferative diseases, and its pathophysiological role was implicated in …