Environmental enrichment protects against stress-induced anxiety: Role of glucocorticoid receptor, ERK, and CREB signaling in the basolateral amygdala

LS Novaes, NB Dos Santos, RFP Batalhote… - …, 2017 - Elsevier
Environmental enrichment (EE) is an experimental animal model that enhances an animal's
opportunity to interact with sensory, motor, and social stimuli, compared to standard …

Environmental enrichment prevents acute restraint stress-induced anxiety-related behavior but not changes in basolateral amygdala spine density

LS Novaes, NB Dos Santos, JG Perfetto… - …, 2018 - Elsevier
Previous studies showed that acute restraint stress or transient elevation of glucocorticoid
(GC) stress hormones produces emergent changes in both anxiety behavior and dendritic …

Differential impact of stress and environmental enrichment on corticolimbic circuits

MA Smail, BL Smith, N Nawreen, JP Herman - … biochemistry and behavior, 2020 - Elsevier
Stress exposure can produce profound changes in physiology and behavior that can impair
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …

Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress

C Fox, Z Merali, C Harrison - Behavioural brain research, 2006 - Elsevier
Environmental enrichment (EE) has beneficial neurobiological, physiological and behavioral
effects. The purpose of the present paper is to review the animal research literature …

Increase of glucocorticoid receptor expression after environmental enrichment: relations to spatial memory, exploration and anxiety-related behaviors

P Sampedro-Piquero, A Begega, JL Arias - Physiology & behavior, 2014 - Elsevier
Environmental enrichment (EE) produces a remarkable degree of structural and functional
plasticity in the hippocampus and possible mediators of these changes, such as …

The neurogenic effects of an enriched environment and its protection against the behavioral consequences of chronic mild stress persistent after enrichment cessation …

NM Vega-Rivera, L Ortiz-López… - Behavioural Brain …, 2016 - Elsevier
Because stress may underlie the presence of depressive episodes, strategies to produce
protection against or to reverse the effects of stress on neuroplasticity and behavior are …

Short-term environmental enrichment is sufficient to counter stress-induced anxiety and associated structural and molecular plasticity in basolateral amygdala

A Ashokan, A Hegde, R Mitra - Psychoneuroendocrinology, 2016 - Elsevier
Moderate levels of anxiety enable individual animals to cope with stressors through
avoidance, and could be an adaptive trait. However, repeated stress exacerbates anxiety to …

Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment

FWF Shum, LJ Wu, MG Zhao, H Toyoda… - Learning & …, 2007 - learnmem.cshlp.org
Exposure to an enriched environment (EE) has been shown to induce cortical plasticity.
Considerable amount of research is focused on the effects of EE in the hippocampus; …

The basolateral amygdala regulates adaptation to stress via β-adrenergic receptor-mediated reductions in phosphorylated extracellular signal-regulated kinase

NM Grissom, S Bhatnagar - Neuroscience, 2011 - Elsevier
The reactivity of physiological systems and behavior to psychological stress is reduced with
increasing familiarity with a repeated stressor. This reduced reactivity, termed habituation, is …

The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1

Y Sztainberg, Y Kuperman, M Tsoory, M Lebow… - Molecular …, 2010 - nature.com
Environmental enrichment (EE) is known to have an anxiolytic effect in several animal
models; however, the molecular mechanisms underlying these behavioral changes are not …