Melanoma develops from a series of architectural and phenotypically distinct stages and
becomes progressively aggressive culminating in metastasis. Over the years, considerable …

The pathogenesis of melanoma is beginning to be better understood due to a broad effort in
defining clinically and pathohistologically the different stages of the disease. Cell culture and …

Recently, several important findings on melanoma development and progression have
accelerated progress towards a molecular understanding of melanoma biology …

Abstract In the United States, Australia, Northern Europe, and Canada, malignant melanoma
is increasing at a faster rate than any other cancer, with the exception of lung cancer in …

Malignant melanoma is one of the most aggressive malignancies in humans and is
responsible for 60–80% of deaths from skin cancers. The 5-year survival of patients with …

Introduction 3. Model of melanoma development and progression 4. Genetic basis of
melanoma 5. Adhesion molecules in melanoma development and progression 6. Growth …

Metastatic melanoma remained for decades without any effective treatment and was thus
considered as a paradigm of cancer resistance. Recent progress with understanding of the …

The characterization of the molecular mechanisms involved in development and
progression of melanoma could be helpful to identify the molecular profiles underlying …

Cutaneous melanoma is a complex disorder characterized by an elevated degree of
heterogeneity, features that place it among the most aggressive types of cancer. Although …

The induction of differentiation, as evidenced by benign growth characteristics, dendritic
morphology, pigmentation capability, and a mature antigenic phenotype, is an attractive …