Plasma kallikrein: the bradykinin-producing enzyme
J Björkqvist, A Jämsä, T Renné - Thrombosis and haemostasis, 2013 - thieme-connect.com
Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma
kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The …
kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The …
Plasma kallikrein inhibitors in cardiovascular disease: an innovative therapeutic approach
D Kolte, Z Shariat-Madar - Cardiology in Review, 2016 - journals.lww.com
Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma
kallikrein, and circulates in plasma bound to high molecular weight kininogen. Plasma …
kallikrein, and circulates in plasma bound to high molecular weight kininogen. Plasma …
[HTML][HTML] Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond
Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK),
historically named the Fletcher factor. Human PKa and tissue kallikreins are serine …
historically named the Fletcher factor. Human PKa and tissue kallikreins are serine …
Structure of plasma and tissue kallikreins
M Pathak, SS Wong, I Dreveny… - Thrombosis and …, 2013 - thieme-connect.com
The kallikrein kinin system (KKS) consists of serine proteases involved in the production of
peptides called kinins, principally bradykinin and Lys-bradykinin (kallidin). The KKS …
peptides called kinins, principally bradykinin and Lys-bradykinin (kallidin). The KKS …
[HTML][HTML] Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI
Essentials• Zymogen PK is activated to PKa and cleaves substrates kininogen and FXII
contributing to bradykinin generation.• Monomeric PKa and dimeric homologue FXI utilize …
contributing to bradykinin generation.• Monomeric PKa and dimeric homologue FXI utilize …
Role of plasma kallikrein in diabetes and metabolism
EP Feener, Q Zhou, W Fickweiler - Thrombosis and …, 2013 - thieme-connect.com
Plasma kallikrein (PK) is a serine protease generated from plasma prekallikrein, an
abundant circulating zymogen expressed by the Klkb1 gene. The physiological actions of …
abundant circulating zymogen expressed by the Klkb1 gene. The physiological actions of …
Human plasma kallikrein-kinin system: physiological and biochemical parameters
JW Bryant, Z Shariat-Madar - Cardiovascular & Hematological …, 2009 - ingentaconnect.com
The plasma kallikrein-kinin system (KKS) plays a critical role in human physiology. The KKS
encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high …
encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high …
Fifty years of research on the plasma kallikrein-kinin system: from protein structure and function to cell biology and in-vivo pathophysiology
IM Sainz, RA Pixley, RW Colman - Thrombosis and …, 2007 - thieme-connect.com
F or forty years my laboratory has been studying the kallikrein-kininogen-kinin system (KKS).
I was challenged by my mentor Dr. Sol Sherry in whose laboratory I was completing my …
I was challenged by my mentor Dr. Sol Sherry in whose laboratory I was completing my …
[HTML][HTML] The plasma kallikrein–kinin system: its evolution from contact activation
AH Schmaier, KR McCrae - Journal of thrombosis and haemostasis, 2007 - Elsevier
The plasma kallikrein–kinin system consists of the proteins factor XII (FXII), prekallikrein
(PK), and high molecular weight kininogen. It was first recognized as a surface‐activated …
(PK), and high molecular weight kininogen. It was first recognized as a surface‐activated …
[HTML][HTML] Inhibition of plasma kallikrein by a highly specific active site blocking antibody
JA Kenniston, RR Faucette, D Martik… - Journal of Biological …, 2014 - ASBMB
Plasma kallikrein (pKal) proteolytically cleaves high molecular weight kininogen to generate
the potent vasodilator and the pro-inflammatory peptide, bradykinin. pKal activity is tightly …
the potent vasodilator and the pro-inflammatory peptide, bradykinin. pKal activity is tightly …