Oral nanozyme-engineered probiotics for the treatment of ulcerative colitis

H Zhao, Y Du, L Liu, Y Du, K Cui, P Yu, L Li… - Journal of Materials …, 2022 - pubs.rsc.org
Probiotic-based therapy for ulcerative colitis (UC) is a novel and promising approach that
has gained much popularity in recent years. However, probiotics may be easily captured …

Nanoprobiotics for remolding the pro-inflammatory microenvironment and microbiome in the treatment of colitis

J Li, M Sun, L Liu, W Yang, A Sun, J Yu, D Liu… - Nano Letters, 2023 - ACS Publications
Despite the great progress of current bacterially based biotherapeutics, their unsatisfying
efficacy and underlying safety problems have limited their clinical application. Herein …

Probiotic‐inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the Gut Microbiome

J Xu, J Xu, T Shi, Y Zhang, F Chen, C Yang… - Advanced …, 2023 - Wiley Online Library
Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …

A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease

F Zeng, Y Shi, C Wu, J Liang, Q Zhong, K Briley… - Journal of …, 2022 - Springer
Inflammatory bowel disease (IBD) is an incurable disease of the gastrointestinal tract with a
lack of effective therapeutic strategies. The proinflammatory microenvironment plays a …

Construction of pH‐Dependent Nanozymes with Oxygen Vacancies as the High‐Efficient Reactive Oxygen Species Scavenger for Oral‐Administrated Anti …

N Zhao, FE Yang, CY Zhao, SW Lv… - Advanced …, 2021 - Wiley Online Library
It is of great significance to eliminate excessive reactive oxygen species (ROS) for treating
inflammatory bowel disease (IBD). Herein, for the first time, a novel nanozyme NiCo2O4 …

Gastrointestinal Microenvironment Responsive Nanoencapsulation of Probiotics and Drugs for Synergistic Therapy of Intestinal Diseases

P Peng, T Feng, X Yang, C Nie, L Yu, R Ding, Q Zhou… - ACS …, 2023 - ACS Publications
The gut microbiota are prominent in preserving intestinal environmental homeostasis and
managing human health, and their dysbiosis has been directly related to many kinds of …

Macrophage-biomimetic liposomes delivery of carbon dots nanozymes ameliorate ulcerative colitis by modulating inflammation pathways and remodeling the redox …

Y Ma, J Zhao, Z Deng, B Gao, C Xu, X Yan… - Chemical Engineering …, 2023 - Elsevier
As a recurrent chronic inflammatory intestinal disease, ulcerative colitis (UC) has seriously
affected the life quality of patients. Numerous studies have demonstrated excessive reactive …

Nanozyme-enhanced probiotic spores regulate the intestinal microenvironment for targeted acute gastroenteritis therapy

G Wei, W Liu, Y Zhang, Z Zhou, Y Wang, X Wang… - Nano Letters, 2024 - ACS Publications
Antibiotic therapeutics to combat intestinal pathogen infections often exacerbate microbiota
dysbiosis and impair mucosal barrier functions. Probiotics are promising strategies, because …

Rational design of orally administered cascade nanozyme for inflammatory bowel disease therapy

Y Yu, X Zhao, X Xu, C Cai, X Tang, Q Zhang… - Advanced …, 2023 - Wiley Online Library
Inflammatory bowel disease (IBD) affects millions of individuals worldwide annually. Enteric
reactive oxygen species (ROS) play critical roles in the physiology and pathology of IBD …

Probiotics Armed with In Situ Mineralized Nanocatalysts and Targeted Biocoatings for Multipronged Treatment of Inflammatory Bowel Disease

T Chen, W Meng, Y Li, X Li, X Yu, J Qi, D Ding… - Nano Letters, 2024 - ACS Publications
While oral probiotics show promise in treating inflammatory bowel disease, the primary
challenge lies in sustaining their activity and retention within the inflamed gastrointestinal …