After three decades of physiological research, the precise nature of the genetic lesion in
Zucker fatty (fa/fa) rats remains unknown. Several methods have been used to identify …

The Zucker (fa/fa) rat is the best-known and most widely used rat model of genetic obesity. In
a recent extensive review of obesity research, Bray et al.(1989) cited over 700 references …

The Zucker-fatty rat (Rattus norvegicus) appeared as a result of a spontaneous mutation in a
cross between the Merck Stock M and Sherman rats. 12''63 The obesity is transmitted as an …

The aim of this study was to discover which of three major abnormalities of the genetically
obese Zucker rat (fa/fa), namely hyperphagia, excess adiposity, and hyperlipidemia, is the …

To find out whether perinatal differences in energy stores are essential for the phenotypic
manifestation of the fa/fa genotype in 16-day-old rats, we investigated Zucker rats (13M) x …

Previously we reported that suckling lean heterozygous (FA/fa) Zucker rats had a number of
adipose tissue measurements intermediate between those of homozygous lean (FA/FA) and …

Factors associated with the development of obesity were compared among obese (fa/fa),
heterozygous (Fa/fa) lean and homozygous (Fa/Fa) lean Zucker rats at 17 d of age. Inguinal …

The autosomal recessive mutations fa (rat) and db (mouse) cause obesity syndromes that
develop early and ultimately become severe. Although both fa/fa rats and db/db mice have …

Different responses to a high fat diet (HFD) can occur even within a group of animals with
the same genetic background, such as obesity-prone (OP) or obesity-resistant (OR) …

To find out whether the most characteristic physiological traits distinguishing suckling-age
fa/fa pups from lean littermates also differ between+/+ and+/fa littermates, we analyzed the …