The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as
core components of the machinery that drives cell cycle progression are well established …

Proper progression throughout the cell division cycle depends on the expression level of a
family of proteins known as cyclins, and the subsequent activation of cyclin-dependent …

Since their initial discovery in yeast, cyclin-dependent kinases have proven to be universal
regulators of the cell cycle in all eukaryotes. In unicellular eukaryotes, cell cycle progression …

Cyclin‐dependent kinases and their regulatory subunits, the cyclins, are known to regulate
progression through the cell cycle. Yet these same proteins are often expressed in non …

Publisher Summary This chapter introduces cyclins and their partner—cyclin dependent
kinases (CDKs)—and the ways in which CDK complexes can be regulated. Cyclins are …

Cyclin-dependent kinase (CDK) activity is essential for eukaryotic cell cycle events. Multiple
cyclins activate CDKs in all eukaryotes, but it is unclear whether multiple cyclins are really …

ABSTRACT A significant portion of cellular scientific literature published is dedicated to
describing the cloning, the link to cancer, or the characterization of proteins involved in the …

Cell cycle progression is driven by the coordinated regulation of the activities of cyclin-
dependent kinases (Cdks). Of the several mechanisms known to regulate Cdk activity in …

Passage through the cell cycle requires the successive activation of different cyclin‐
dependent protein kinases (CDKs). These enzymes are controlled by transient associations …

Cyclins and cyclin-dependent kinases (Cdks) are universal regulators of cell cycle
progression in eukaryotic cells. Cdk activity is controlled by phosphorylation at three …