Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle
BE Cairns, P Svensson, K Wang… - Journal of …, 2003 - journals.physiology.org
Peripheral N-methyl-d-aspartate (NMDA) receptors are found in deep tissues and may play
a role in deep tissue pain. Injection of the endogenous NMDA receptor agonist glutamate …
a role in deep tissue pain. Injection of the endogenous NMDA receptor agonist glutamate …
Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males
BE Cairns, P Svensson, K Wang, E Castrillon… - Experimental brain …, 2006 - Springer
The purpose of the present study was to determine whether glutamate-induced mechanical
sensitization of the masseter muscle in human volunteers involves activation of peripheral N …
sensitization of the masseter muscle in human volunteers involves activation of peripheral N …
Systemic administration of monosodium glutamate elevates intramuscular glutamate levels and sensitizes rat masseter muscle afferent fibers
BE Cairns, X Dong, MK Mann, P Svensson, BJ Sessle… - Pain, 2007 - Elsevier
There is evidence that elevated tissue concentrations of glutamate may contribute to pain
and sensitivity in certain musculoskeletal pain conditions. In the present study, the food …
and sensitivity in certain musculoskeletal pain conditions. In the present study, the food …
[HTML][HTML] Activation of NMDA receptors in the brainstem, rostral ventromedial medulla, and nucleus reticularis gigantocellularis mediates mechanical hyperalgesia …
Repeated injections of acidic saline into the gastrocnemius muscle induce both muscle and
cutaneous hypersensitivity. We have previously shown that microinjection of local anesthetic …
cutaneous hypersensitivity. We have previously shown that microinjection of local anesthetic …
Comparison of glutamate-evoked pain between the temporalis and masseter muscles in men and women
Pain in myofascial temporomandibular disorder (TMD) can affect both the masseter and
temporalis muscles. Glutamate injection into the masseter muscle evokes pain that is greater …
temporalis muscles. Glutamate injection into the masseter muscle evokes pain that is greater …
Peripheral administration of NMDA, AMPA or KA results in pain behaviors in rats
S Zhou, L Bonasera, SM Carlton - Neuroreport, 1996 - journals.lww.com
The present study investigated the role of N-methyl-D-aspartate (NMDA) and non-NMDA
glutamate receptor subtypes in peripheral pain transmission. Activation of NMDA,[alpha] …
glutamate receptor subtypes in peripheral pain transmission. Activation of NMDA,[alpha] …
Intrathecal N-methyl-D-aspartate induces hyperexcitability in rat dorsal horn convergent neurones
GD Sher, D Mitchell - Neuroscience letters, 1990 - Elsevier
We have investigated the effects of intrathecal (it) N-methyl-d-aspartate (NMDA) and an
NMDA antagonist d-2-amino-5-phosphonovalerate (APV) on spontaneous and evoked …
NMDA antagonist d-2-amino-5-phosphonovalerate (APV) on spontaneous and evoked …
Endogenous activation of presynaptic NMDA receptors enhances glutamate release from the primary afferents in the spinal dorsal horn in a rat model of neuropathic …
Key points• Activation of N‐methyl‐d‐aspartate (NMDA) receptors (NMDARs) is a crucial
mechanism underlying the development and maintenance of pain.• Little is known about the …
mechanism underlying the development and maintenance of pain.• Little is known about the …
N-methyl-D-aspartate-induced excitation and sensitization of normal and inflamed nociceptors
J Du, S Zhou, RE Coggeshall, SM Carlton - Neuroscience, 2003 - Elsevier
The present study investigates the contribution of peripheral N-methyl-d-aspartate (NMDA)
receptors to acute nociception and persistent inflammatory pain in the rat …
receptors to acute nociception and persistent inflammatory pain in the rat …
Sex-related differences in human pain and rat afferent discharge evoked by injection of glutamate into the masseter muscle
BE Cairns, JW Hu, L Arendt-Nielsen… - Journal of …, 2001 - journals.physiology.org
Animal studies have suggested that tissue injury–related increased levels of glutamate may
be involved in peripheral nociceptive mechanisms in deep craniofacial tissues. Indeed …
be involved in peripheral nociceptive mechanisms in deep craniofacial tissues. Indeed …