Background Metastatic colorectal cancer (CRC) is associated with highly variable clinical
outcome and response to therapy. The recently identified consensus molecular subtypes …

Gene expression-based subtypes of colorectal cancer have clinical relevance, but the
representativeness of primary tumors and the consensus molecular subtypes (CMS) for …

Metastatic progression of colorectal adenocarcinoma (CRC) remains poorly understood and
poses significant challenges for treatment. To overcome these challenges, we performed …

Colorectal cancer (CRC) has clinically relevant molecular heterogeneity at multiple levels:
genomics, epigenomics, transcriptomics, and microenvironment features. Genomic events …

Liver is the most common site where metastatic lesions of colorectal cancer (CRC) arise.
Although researches have shown mutations in driver genes, copy number variations (CNV) …

Simple Summary Liver metastasis remains a major hurdle to the long-lasting survival of
patients with colorectal cancer (CRC). When CRC spreads to the liver, tumor cells undergo a …

Background: Colorectal cancer, the fourth leading cause of cancer mortality, is prone to
metastasis, especially to the liver. The pre-metastatic microenvironment comprising various …

Background Because of the heterogeneity of metastatic colorectal cancer (mCRC), a
genome‐wide analysis was performed to characterize the tumor immune microenvironment …

Importance Personalized treatment approaches for patients with oligometastatic colorectal
liver metastases are critically needed. We previously defined 3 biologically distinct …

Simple Summary Colorectal cancer (CRC) is the second most common cause of cancer-
related mortality in the United States. Despite best efforts, 5-year survival for unresectable …