The dual role of interleukin-6 in Crohn's disease pathophysiology

A Alhendi, SA Naser - Frontiers in Immunology, 2023 - frontiersin.org
Interleukin-6 (IL-6) is a key mediator cytokine of the immune response as well as a regulator
of many physiological and pathological processes. In Crohn's disease (CD), cytokine …

Role of the IL23/IL17 Pathway in Crohn's Disease

H Schmitt, MF Neurath, R Atreya - Frontiers in Immunology, 2021 - frontiersin.org
Crohn's disease (CD) is a chronic relapsing disorder of the gastrointestinal tract and
represents one of the main entities of inflammatory bowel disease (IBD). CD affects …

IL-6 and Crohn's disease

H Ito - Current Drug Targets-Inflammation & Allergy, 2003 - ingentaconnect.com
Interleukin-6 (IL-6) is a pleiotropic cytokine with central roles in immune regulation,
inflammation, hematopoiesis, and oncogenesis. Its biological activities are shared by IL-6 …

Anti-IL-6 treatment for inflammatory bowel diseases: next cytokine, next target

M Allocca, M Jovani, G Fiorino, S Schreiber… - Current drug …, 2013 - ingentaconnect.com
Inflammatory bowel diseases (IBD) are chronic, relapsing, and destructive inflammatory
disorders of the gastrointestinal tract. Both Crohn's disease (CD) and ulcerative colitis (UC) …

Novel therapy for Crohn's disease targeting IL-6 signalling

H Ito - Expert opinion on therapeutic targets, 2004 - Taylor & Francis
The aetiology of Crohn's disease (CD) remains unknown, however, the importance of pro-
inflammatory cytokines including IL-6 has been shown. IL-6 can transduce its signal into the …

Serum interleukin 9 levels predict disease severity and the clinical efficacy of infliximab in patients with Crohn's disease

T Feng, B Chen, L Li, S Huang… - Inflammatory bowel …, 2017 - academic.oup.com
Background Interleukin (IL)-9 drives gut inflammation, but its role in Crohn's disease (CD) is
unclear. We aimed to analyze correlations between serum IL-9 levels and disease severity …

Cytokines of the interleukin-6 family as emerging targets in inflammatory bowel disease

C Garbers, J Lokau - Expert Opinion on Therapeutic Targets, 2024 - Taylor & Francis
Introduction Inflammatory bowel disease (IBD) is an umbrella term that includes different
chronic inflammatory diseases of the gastrointestinal tract, most commonly Crohn's disease …

Insights into the molecular mechanisms and therapeutic implications of interleukin-6 for inflammatory bowel disease

Y Tie, M Chen, S Zhang - Chinese Medical Journal, 2023 - journals.lww.com
Inflammatory bowel disease (IBD) is a debilitating chronic inflammatory disorder that
primarily affects the digestive system, which mainly encompasses Crohn's disease (CD) and …

Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development

MJ Waldner, MF Neurath - Seminars in immunology, 2014 - Elsevier
IL-6 signaling is of central importance for the maintenance of chronic intestinal inflammation
in inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. IL-6 …

Crohn's disease and IL-10 therapy: Promise regained?

BE Sands - Inflammatory Bowel Diseases, 2003 - academic.oup.com
Recent therapeutic strategies for Crohn's disease (CD) target cytokines and their receptors
specifically. The concept of neutralization of pro-inflammatory cytokines, in particular tumor …