The dual role of interleukin-6 in Crohn's disease pathophysiology
Interleukin-6 (IL-6) is a key mediator cytokine of the immune response as well as a regulator
of many physiological and pathological processes. In Crohn's disease (CD), cytokine …
of many physiological and pathological processes. In Crohn's disease (CD), cytokine …
Role of the IL23/IL17 Pathway in Crohn's Disease
H Schmitt, MF Neurath, R Atreya - Frontiers in Immunology, 2021 - frontiersin.org
Crohn's disease (CD) is a chronic relapsing disorder of the gastrointestinal tract and
represents one of the main entities of inflammatory bowel disease (IBD). CD affects …
represents one of the main entities of inflammatory bowel disease (IBD). CD affects …
IL-6 and Crohn's disease
H Ito - Current Drug Targets-Inflammation & Allergy, 2003 - ingentaconnect.com
Interleukin-6 (IL-6) is a pleiotropic cytokine with central roles in immune regulation,
inflammation, hematopoiesis, and oncogenesis. Its biological activities are shared by IL-6 …
inflammation, hematopoiesis, and oncogenesis. Its biological activities are shared by IL-6 …
Anti-IL-6 treatment for inflammatory bowel diseases: next cytokine, next target
Inflammatory bowel diseases (IBD) are chronic, relapsing, and destructive inflammatory
disorders of the gastrointestinal tract. Both Crohn's disease (CD) and ulcerative colitis (UC) …
disorders of the gastrointestinal tract. Both Crohn's disease (CD) and ulcerative colitis (UC) …
Novel therapy for Crohn's disease targeting IL-6 signalling
H Ito - Expert opinion on therapeutic targets, 2004 - Taylor & Francis
The aetiology of Crohn's disease (CD) remains unknown, however, the importance of pro-
inflammatory cytokines including IL-6 has been shown. IL-6 can transduce its signal into the …
inflammatory cytokines including IL-6 has been shown. IL-6 can transduce its signal into the …
Serum interleukin 9 levels predict disease severity and the clinical efficacy of infliximab in patients with Crohn's disease
T Feng, B Chen, L Li, S Huang… - Inflammatory bowel …, 2017 - academic.oup.com
Background Interleukin (IL)-9 drives gut inflammation, but its role in Crohn's disease (CD) is
unclear. We aimed to analyze correlations between serum IL-9 levels and disease severity …
unclear. We aimed to analyze correlations between serum IL-9 levels and disease severity …
Cytokines of the interleukin-6 family as emerging targets in inflammatory bowel disease
Introduction Inflammatory bowel disease (IBD) is an umbrella term that includes different
chronic inflammatory diseases of the gastrointestinal tract, most commonly Crohn's disease …
chronic inflammatory diseases of the gastrointestinal tract, most commonly Crohn's disease …
Insights into the molecular mechanisms and therapeutic implications of interleukin-6 for inflammatory bowel disease
Y Tie, M Chen, S Zhang - Chinese Medical Journal, 2023 - journals.lww.com
Inflammatory bowel disease (IBD) is a debilitating chronic inflammatory disorder that
primarily affects the digestive system, which mainly encompasses Crohn's disease (CD) and …
primarily affects the digestive system, which mainly encompasses Crohn's disease (CD) and …
Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development
MJ Waldner, MF Neurath - Seminars in immunology, 2014 - Elsevier
IL-6 signaling is of central importance for the maintenance of chronic intestinal inflammation
in inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. IL-6 …
in inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. IL-6 …
Crohn's disease and IL-10 therapy: Promise regained?
BE Sands - Inflammatory Bowel Diseases, 2003 - academic.oup.com
Recent therapeutic strategies for Crohn's disease (CD) target cytokines and their receptors
specifically. The concept of neutralization of pro-inflammatory cytokines, in particular tumor …
specifically. The concept of neutralization of pro-inflammatory cytokines, in particular tumor …