Placenta growth factor, PLGF, influences the motility of lung cancer cells, the role of Rho associated kinase, Rock1
Placenta growth factor (PlGF) is a member of the VEGF family and has been implicated in
the aggressive capacity of solid tumours, partly via its impact on angiogenesis. The present …
the aggressive capacity of solid tumours, partly via its impact on angiogenesis. The present …
[HTML][HTML] Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers
A Eriksson, R Cao, R Pawliuk, SM Berg, M Tsang… - Cancer cell, 2002 - cell.com
Tumor growth and metastasis require concomitant growth of new blood vessels, which are
stimulated by angiogenic factors, including vascular endothelial growth factor (VEGF) …
stimulated by angiogenic factors, including vascular endothelial growth factor (VEGF) …
[HTML][HTML] Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and …
M Autiero, A Luttun, M Tjwa, P Carmeliet - Journal of Thrombosis and …, 2003 - Elsevier
In contrast to VEGF and its receptor VEGFR-2, PlGF and its receptor VEGFR-1 have been
largely neglected and therefore their potential for therapy has not been previously explored …
largely neglected and therefore their potential for therapy has not been previously explored …
A placental growth factor variant unable to recognize vascular endothelial growth factor (VEGF) receptor-1 inhibits VEGF-dependent tumor angiogenesis via …
V Tarallo, L Vesci, O Capasso, MT Esposito, T Riccioni… - Cancer research, 2010 - AACR
Angiogenesis is one of the crucial events for cancer development and growth. Two members
of the vascular endothelial growth factor (VEGF) family, VEGF-A and placental growth factor …
of the vascular endothelial growth factor (VEGF) family, VEGF-A and placental growth factor …
[HTML][HTML] Flt-1 in colorectal cancer cells is required for the tumor invasive effect of placental growth factor through a p38-MMP9 pathway
Abstract Background Placenta growth factor (PlGF), a dimeric glycoprotein with 53%
homology to VEGF, binds to VEGF receptor-1 (Flt-1), but not to VEGF receptor-2 (Flk-1), and …
homology to VEGF, binds to VEGF receptor-1 (Flt-1), but not to VEGF receptor-2 (Flk-1), and …
[HTML][HTML] The discovery of placenta growth factor and its biological activity
S De Falco - Experimental & molecular medicine, 2012 - nature.com
Angiogenesis is a complex biological phenomenon crucial for a correct embryonic
development and for post-natal growth. In adult life, it is a tightly regulated process confined …
development and for post-natal growth. In adult life, it is a tightly regulated process confined …
Placental growth factor-1 attenuates vascular endothelial growth factor-A–dependent tumor angiogenesis during β cell carcinogenesis
T Schomber, L Kopfstein, V Djonov, I Albrecht… - Cancer Research, 2007 - AACR
Members of the vascular endothelial growth factor (VEGF) family are critical players in
angiogenesis and lymphangiogenesis. Although VEGF-A has been shown to exert …
angiogenesis and lymphangiogenesis. Although VEGF-A has been shown to exert …
Altered tumor vessel maturation and proliferation in placenta growth factor‐producing tumors: potential relationship to post‐therapy tumor angiogenesis and …
AP Taylor, M Rodriguez, K Adams… - … journal of cancer, 2003 - Wiley Online Library
Cells in human tumor xenografts express similar levels of angiogenic growth factors before
treatment. After radioimmunotherapy (RAIT) surviving tumor cells upregulate angiogenic …
treatment. After radioimmunotherapy (RAIT) surviving tumor cells upregulate angiogenic …
PGF isoforms, PLGF-1 and PGF-2 and the PGF receptor, neuropilin, in human breast cancer: prognostic significance
A Escudero-Esparza, TA Martin… - Oncology …, 2010 - spandidos-publications.com
Placenta growth factor (PLGF) is a member of the vascular endothelial growth factor (VEGF)
family, a group of angiogenic growth factors. Recently, isoforms have been identified. This …
family, a group of angiogenic growth factors. Recently, isoforms have been identified. This …
[HTML][HTML] Placental growth factor is secreted by the human endometrium and has potential important functions during embryo development and implantation
Embryo implantation requires synchronized dialogue between the receptive endometrium
and activated blastocyst via locally produced soluble mediators. During the mid-secretory …
and activated blastocyst via locally produced soluble mediators. During the mid-secretory …