Atherosclerosis: orchestrating cells and biomolecules involved in its activation and inhibition

A Munjal, R Khandia - Advances in protein chemistry and structural biology, 2020 - Elsevier
The term atherosclerosis refers to the condition of deposition of lipids and other substances
in and on the artery walls, called as plaque that restricts the normal blood flow. The plaque …

Interleukins in atherosclerosis: molecular pathways and therapeutic potential

JH Von der Thüsen, J Kuiper, TJC Van Berkel… - Pharmacological …, 2003 - ASPET
Interleukins are considered to be key players in the chronic vascular inflammatory response
that is typical of atherosclerosis. Thus, the expression of proinflammatory interleukins and …

Atherosclerosis: role of chemokines and macrophages

AD Lucas, DR Greaves - Expert reviews in molecular medicine, 2001 - cambridge.org
Atherosclerosis is a pathological process that takes place in the major arteries and is the
underlying cause of heart attacks, stroke and peripheral artery disease. The earliest …

Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis

PJ Little, A Chait, A Bobik - Pharmacology & therapeutics, 2011 - Elsevier
Cardiovascular disease is the largest cause of morbidity and premature mortality and its
major underlying pathology is atherosclerosis. Atherosclerosis commences with the …

Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation

S Kofler, T Nickel, M Weis - Clinical science, 2005 - portlandpress.com
Complex cellular and inflammatory interactions are involved in the progress of vascular
diseases. Endothelial cells, upon exposure to cytokines, undergo profound alterations of …

[HTML][HTML] Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery

T Gui, A Shimokado, Y Sun, T Akasaka… - Mediators of …, 2012 - hindawi.com
Cardiovascular disease, a leading cause of mortality in developed countries, is mainly
caused by atherosclerosis, a chronic inflammatory disease. Macrophages, which …

[HTML][HTML] Vascular macrophages in atherosclerosis

H Xu, J Jiang, W Chen, W Li, Z Chen - Journal of immunology …, 2019 - hindawi.com
Atherosclerosis is the main pathological basis for the occurrence of most cardiovascular
diseases, the leading global health threat, and a great burden for society. It has been well …

Atherosclerosis as an inflammatory disease

A Tuttolomondo, D Di Raimondo… - Current …, 2012 - ingentaconnect.com
In many ways, atherosclerosis is a chronic inflammatory disorder and this issue is confirmed
by recent investigations of that have focused on inflammation, providing new insight into …

Macrophages and immune cells in atherosclerosis: recent advances and novel concepts

C Cochain, A Zernecke - Basic research in cardiology, 2015 - Springer
Atherosclerotic lesion-related thrombosis is the major cause of myocardial infarction and
stroke, which together constitute the leading cause of mortality worldwide. The inflammatory …

[HTML][HTML] Anti-inflammatory therapy for atherosclerosis: focusing on cytokines

AV Poznyak, D Bharadwaj, G Prasad… - International journal of …, 2021 - mdpi.com
Atherosclerosis is a well-known global health problem. Despite the high prevalence of the
disease, numerous aspects of pathogenesis remain unclear. Subsequently, there are still no …