Macrophages are becoming increasingly recognized as key agents in chronic diseases of
aging, including cancer, metabolic disease, and, the topic of this review, atherosclerosis. In …

Atherosclerosis is a chronic progressive disease that involves damage to the intima,
inflammatory cell recruitment and the accumulation of lipids followed by calcification and …

Atherosclerosis is the most life-threatening pathology worldwide. Its major clinical
complications, stroke, myocardial infarction, and heart failure, are on the rise in many …

Abstract inflammation is a process that plays an important role in the initiation and
progression of atherosclerosis and immune disease, involving multiple cell types, including …

Atherosclerosis constitutes the underlying disease to the clinical manifestations of
myocardial infarction, stroke, and gangrene. Despite the success of statins, prevention of …

Until recently, most envisaged atherosclerosis as a bland arterial collection of cholesterol,
complicated by smooth muscle cell accumulation. According to that concept, endothelial …

Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Many molecular and cellular mechanisms link inflammation and haemostatic mechanisms.
Inflammation, and perhaps chronic infection, may play important roles in the initiation and …

Inflammation orchestrates each stage of the life cycle of atherosclerotic plaques. Indeed,
inflammatory mediators likely link many traditional and emerging risk factors with …