Prostaglandin E2 (PGE2)–EP2 signaling negatively regulates murine atopic dermatitis–like skin inflammation by suppressing thymic stromal lymphopoietin expression
Background Atopic dermatitis (AD) is a common and chronic inflammatory skin disease of
type 2 immunity. Keratinocyte-derived cytokines, including thymic stromal lymphopoietin …
type 2 immunity. Keratinocyte-derived cytokines, including thymic stromal lymphopoietin …
Counterregulation between thymic stromal lymphopoietin–and IL-23–driven immune axes shapes skin inflammation in mice with epidermal barrier defects
J Li, JM Leyva-Castillo, P Hener, A Eisenmann… - Journal of Allergy and …, 2016 - Elsevier
Background Epidermal barrier dysfunction has been recognized as a critical factor in the
initiation and exacerbation of skin inflammation, particularly in patients with atopic dermatitis …
initiation and exacerbation of skin inflammation, particularly in patients with atopic dermatitis …
Thymic stromal lymphopoietin‐induced interleukin‐17 A is involved in the development of I g E‐mediated atopic dermatitis‐like skin lesions in mice
Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with elevated levels
of allergen‐specific IgE. Although thymic stromal lymphopoietin (TSLP) and interleukin‐17A …
of allergen‐specific IgE. Although thymic stromal lymphopoietin (TSLP) and interleukin‐17A …
[HTML][HTML] IL-33 promotes gastrointestinal allergy in a TSLP-independent manner
H Han, F Roan, LK Johnston, DE Smith, PJ Bryce… - Mucosal …, 2018 - Elsevier
Atopic dermatitis (AD) often precedes asthma and food allergy, indicating that epicutaneous
sensitization to allergens may be important in the induction of allergic responses at other …
sensitization to allergens may be important in the induction of allergic responses at other …
IL‐33 induces Egr‐1‐dependent TSLP expression via the MAPK pathways in human keratinocytes
WI Ryu, H Lee, JH Kim, HC Bae… - Experimental …, 2015 - Wiley Online Library
Atopic dermatitis (AD) is a chronic inflammatory skin disease in which T‐helper type 2 (Th2)‐
type immune responses are dominant. Th2 cytokine, interleukin (IL)‐33 and thymic stromal …
type immune responses are dominant. Th2 cytokine, interleukin (IL)‐33 and thymic stromal …
[HTML][HTML] TSLP produced by keratinocytes promotes allergen sensitization through skin and thereby triggers atopic march in mice
JM Leyva-Castillo, P Hener, H Jiang, M Li - Journal of Investigative …, 2013 - Elsevier
Atopic dermatitis often precedes the development of asthma, a phenomenon known as
“atopic march”. An important role of allergen sensitization developed through barrier …
“atopic march”. An important role of allergen sensitization developed through barrier …
Thymic stromal lymphopoietin rather than IL-33 drives food allergy after epicutaneous sensitization to food allergen
EB Brandt, BP Ruff, AL Filuta, WC Chang, D Shik… - Journal of Allergy and …, 2023 - Elsevier
Background A major route of sensitization to food allergen is through an impaired skin
barrier. IL-33 and thymic stromal lymphopoietin (TSLP) have both been implicated in …
barrier. IL-33 and thymic stromal lymphopoietin (TSLP) have both been implicated in …
The role of thymic stromal lymphopoietin in the immunopathogenesis of atopic dermatitis
SP Jariwala, E Abrams, A Benson… - Clinical & …, 2011 - Wiley Online Library
Atopic dermatitis (AD), a skin disease characterized by pruritus and chronic inflammation,
results from a complex interplay between environmental and genetic factors. Thymic stromal …
results from a complex interplay between environmental and genetic factors. Thymic stromal …
[HTML][HTML] The role of TSLP in IL-13-induced atopic march
Although atopic dermatitis (AD) is the initial step of the “atopic march”, a progression from
AD to asthma, the underlying mechanism remains unknown. Selective expression of IL-13 in …
AD to asthma, the underlying mechanism remains unknown. Selective expression of IL-13 in …
Thymic stromal lymphopoietin is a critical mediator of IL‐13‐driven allergic inflammation
M Miyata, Y Nakamura, N Shimokawa… - European journal of …, 2009 - Wiley Online Library
Both thymic stromal lymphopoietin (TSLP) and IL‐13 are essential cytokines for the
development of allergic inflammation. However, a causal link between TSLP and IL‐13 has …
development of allergic inflammation. However, a causal link between TSLP and IL‐13 has …
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