Cell therapies for spinal cord injury: a review of the clinical trials and cell-type therapeutic potential

BF Ribeiro, BC da Cruz, BM de Sousa, PD Correia… - Brain, 2023 - academic.oup.com
Spinal cord injury (SCI) is an as yet untreatable neuropathology that causes severe
dysfunction and disability. Cell-based therapies hold neuroregenerative and neuroprotective …

[HTML][HTML] Biomaterial-supported MSC transplantation enhances cell–cell communication for spinal cord injury

B Lv, X Zhang, J Yuan, Y Chen, H Ding, X Cao… - Stem Cell Research & …, 2021 - Springer
The spinal cord is part of the central nervous system (CNS) and serves to connect the brain
to the peripheral nervous system and peripheral tissues. The cell types that primarily …

[HTML][HTML] Mesenchymal stem cells for spinal cord injury: current options, limitations, and future of cell therapy

F Cofano, M Boido, M Monticelli, F Zenga… - International journal of …, 2019 - mdpi.com
Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial
phase in the pathophysiological process of SCI concerns the well-known secondary injury …

Neural stem/progenitor cell transplantation for spinal cord injury treatment; A systematic review and meta-analysis

M Yousefifard, V Rahimi-Movaghar, F Nasirinezhad… - Neuroscience, 2016 - Elsevier
Despite the vast improvements of cell therapy in spinal cord injury treatment, no optimum
protocol has been developed for application of neural stem/progenitor cells. In this regard …

[HTML][HTML] Combining cell therapy with human autologous Schwann cell and bone marrow-derived mesenchymal stem cell in patients with subacute complete spinal …

S Oraee-Yazdani, M Akhlaghpasand… - Stem Cell Research & …, 2021 - Springer
Background Cellular transplantations have promising effects on treating spinal cord injury
(SCI) patients. Mesenchymal stem cells (MSCs) and Schwann cells (SCs), which have safety …

Review of transplantation of neural stem/progenitor cells for spinal cord injury

AJ Mothe, CH Tator - International Journal of Developmental Neuroscience, 2013 - Elsevier
Spinal cord injury (SCI) is a debilitating condition often resulting in paralysis, yet currently
there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy …

[HTML][HTML] Advanced approaches to regenerate spinal cord injury: the development of cell and tissue engineering therapy and combinational treatments

J Saremi, N Mahmoodi, M Rasouli, FE Ranjbar… - Biomedicine & …, 2022 - Elsevier
Spinal cord injury (SCI) is a central nervous system (CNS) devastate event that is commonly
caused by traumatic or non-traumatic events. The reinnervation of spinal cord axons is …

[HTML][HTML] Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair

J Li, W Luo, C Xiao, J Zhao, C Xiang, W Liu, R Gu - Theranostics, 2023 - ncbi.nlm.nih.gov
Traumatic spinal cord injury (SCI) can cause severe neurological impairments. Clinically
available treatments are quite limited, with unsatisfactory remediation effects. Residing …

Corticospinal motor circuit plasticity after spinal cord injury: harnessing neuroplasticity to improve functional outcomes

SF Kazim, CA Bowers, CD Cole, S Varela… - Molecular …, 2021 - Springer
Spinal cord injury (SCI) is a devastating condition that affects approximately 294,000 people
in the USA and several millions worldwide. The corticospinal motor circuitry plays a major …

Cell-based transplantation strategies to promote plasticity following spinal cord injury

CA Ruff, JT Wilcox, MG Fehlings - Experimental neurology, 2012 - Elsevier
Cell transplantation therapy holds potential for repair and functional plasticity following
spinal cord injury (SCI). Stem and progenitor cells are capable of modifying the lesion …