Targeted therapies using electrical and magnetic neural stimulation for the treatment of chronic pain in spinal cord injury

I Moreno-Duarte, LR Morse, M Alam, M Bikson… - Neuroimage, 2014 - Elsevier
Background Chronic neuropathic pain is one of the most common and disabling symptoms
in individuals with spinal cord injury (SCI). Over two-thirds of subjects with SCI suffer from …

Spinal cord injuries: how could cell therapy help?

A Badner, AM Siddiqui, MG Fehlings - Expert opinion on biological …, 2017 - Taylor & Francis
Introduction: Spinal cord injury (SCI) is a devastating condition, where regenerative failure
and cell loss lead to paralysis. The heterogeneous and time-sensitive pathophysiology has …

Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury

M Abematsu, K Tsujimura, M Yamano… - The Journal of …, 2010 - Am Soc Clin Investig
The body's capacity to restore damaged neural networks in the injured CNS is severely
limited. Although various treatment regimens can partially alleviate spinal cord injury (SCI) …

Neural stem cells: promoting axonal regeneration and spinal cord connectivity

CM de Freria, E Van Niekerk, A Blesch, P Lu - Cells, 2021 - mdpi.com
Spinal cord injury (SCI) leads to irreversible functional impairment caused by neuronal loss
and the disruption of neuronal connections across the injury site. While several experimental …

The translational landscape in spinal cord injury: focus on neuroplasticity and regeneration

TH Hutson, S Di Giovanni - Nature Reviews Neurology, 2019 - nature.com
Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …

Clinical study of NeuroRegen scaffold combined with human mesenchymal stem cells for the repair of chronic complete spinal cord injury

Y Zhao, F Tang, Z Xiao, G Han, N Wang… - Cell …, 2017 - journals.sagepub.com
Regeneration of damaged neurons and recovery of sensation and motor function after
complete spinal cord injury (SCI) are challenging. We previously developed a collagen …

Transplantation of cerebral dopamine neurotrophic factor transducted BMSCs in contusion spinal cord injury of rats: promotion of nerve regeneration by alleviating …

H Zhao, L Cheng, X Du, Y Hou, Y Liu, Z Cui… - Molecular neurobiology, 2016 - Springer
Traumatic spinal cord injury (SCI) causes neuron death and axonal damage resulting in
functional motor and sensory loss, showing limited regeneration because of adverse …

Rehabilitation technologies and interventions for individuals with spinal cord injury: translational potential of current trends

KE Musselman, M Shah, J Zariffa - Journal of neuroengineering and …, 2018 - Springer
In the past, neurorehabilitation for individuals with neurological damage, such as spinal cord
injury (SCI), was focused on learning compensatory movements to regain function …

Combination of multifaceted strategies to maximize the therapeutic benefits of neural stem cell transplantation for spinal cord repair

DH Hwang, HM Kim, YM Kang, IS Joo… - Cell …, 2011 - journals.sagepub.com
Neural stem cells (NSCs) possess therapeutic potentials to reverse complex pathological
processes following spinal cord injury (SCI), but many obstacles remain that could not be …

Cell transplantation therapy for spinal cord injury

P Assinck, GJ Duncan, BJ Hilton, JR Plemel… - Nature …, 2017 - nature.com
Spinal cord injury can lead to severe motor, sensory and autonomic dysfunction. Currently,
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …