Cell transplantation therapy for spinal cord injury

P Assinck, GJ Duncan, BJ Hilton, JR Plemel… - Nature …, 2017 - nature.com
Spinal cord injury can lead to severe motor, sensory and autonomic dysfunction. Currently,
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …

Regeneration of spinal cord connectivity through stem cell transplantation and biomaterial scaffolds

H Katoh, K Yokota, MG Fehlings - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Significant progress has been made in the treatment of spinal cord injury (SCI). Advances in
post-trauma management and intensive rehabilitation have significantly improved the …

Strategies and prospects of effective neural circuits reconstruction after spinal cord injury

B Yang, F Zhang, F Cheng, L Ying, C Wang, K Shi… - Cell Death & …, 2020 - nature.com
Due to the disconnection of surviving neural elements after spinal cord injury (SCI), such
patients had to suffer irreversible loss of motor or sensory function, and thereafter enormous …

Stem cell-based therapy for spinal cord injury

V Volarevic, S Erceg, SS Bhattacharya… - Cell …, 2013 - journals.sagepub.com
Stem cells (SCs) represent a new therapeutic approach for spinal cord injury (SCI) by
enabling improved sensory and motor functions in animal models. The main goal of SC …

Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury

N Wenger, EM Moraud, S Raspopovic… - Science translational …, 2014 - science.org
Neuromodulation of spinal sensorimotor circuits improves motor control in animal models
and humans with spinal cord injury. With common neuromodulation devices, electrical …

Direct neuronal differentiation of neural stem cells for spinal cord injury repair

W Xue, C Fan, B Chen, Y Zhao, Z Xiao, J Dai - Stem Cells, 2021 - academic.oup.com
Spinal cord injury (SCI) typically results in long-lasting functional deficits, largely due to
primary and secondary wh ite matter damage at the site of injury. The transplantation of …

Translating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injury

AM Siddiqui, M Khazaei, MG Fehlings - Progress in brain research, 2015 - Elsevier
One of the big challenges in neuroscience that remains to be understood is why the central
nervous system is not able to regenerate to the extent that the peripheral nervous system …

Advances in regenerative therapies for spinal cord injury: a biomaterials approach

M Tsintou, K Dalamagkas… - Neural regeneration …, 2015 - journals.lww.com
Spinal cord injury results in the permanent loss of function, causing enormous personal,
social and economic problems. Even though neural regeneration has been proven to be a …

Sustained delivery of neurotrophic factors to treat spinal cord injury

A Muheremu, L Shu, J Liang, A Aili… - Translational …, 2021 - degruyter.com
Acute spinal cord injury (SCI) is a devastating condition that results in tremendous physical
and psychological harm and a series of socioeconomic problems. Although neurons in the …

Mesenchymal cells in the treatment of spinal cord injury: current & future perspectives

R Vawda, MG Fehlings - Current stem cell research & therapy, 2013 - ingentaconnect.com
Nearly 1.5 million people in the US live with a spinal cord injury (SCI). The cost to the
healthcare system is estimated at over $10 billion annually likely because over 65% of SCIs …