Idiopathic pneumonia syndrome (IPS) is a frequently fatal complication after allogeneic stem
cell transplantation (allo-SCT) that responds poorly to standard immunosuppressive therapy …

Activation of the chemokine receptor CXCR3 by its cognate ligands induces several
differentiated cellular responses important to the growth and migration of a variety of …

In pulmonary inflammation, recruitment of circulating polymorphonuclear leukocytes is
essential for host defense and initiates the following specific immune response. One …

Outcomes following lung transplant are suboptimal owing to chronic allograft failure termed
bronchiolitis obliterans syndrome (BOS). Prior work in both mice and humans has shown …

Background Chemokine receptors (CR) play an important role in T cell migration, but their
contribution to lung trafficking is unclear. Objective We hypothesized that if a particular CR …

Th1 cells are implicated in numerous pulmonary inflammatory disorders, and adoptive
transfer of alloreactive Th1 cells mediates lung injury and inflammation in mice. In response …

The chemokine receptor CXCR6 is highly expressed on lung-derived T cells compared to
blood T cells, especially in inflammatory diseases characterised by T-cell migration to the …

Chemokine receptors control several fundamental cellular processes in both hematopoietic
and structural cells, including directed cell movement, ie, chemotaxis, cell differentiation, and …

Introduction: CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2)
have been shown to play an important role in transepithelial migration of neutrophil …

Trafficking and recruitment of immune cells to the site of inflammation with spatial and
temporal synchronization is crucial for the development of allergic airway inflammation …