Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates cellular and
systemic homeostatic responses to reduced O2 availability in mammals, including …

Hypoxia induces a group of physiologically important genes such as erythropoietin and
vascular endothelial growth factor. These genes are transcriptionally up-regulated by …

The adaptive response to hypoxia involves the transcriptional induction of three transcription
factors called hypoxia inducible factor alpha 1, 2 and 3 (HIF-1α, HIF-2α, and HIF-3α) which …

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls
angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes …

Hypoxia‐inducible factor 1 (HIF‐1) is a heterodimeric transcription factor composed of HIF‐
1α and HIF‐1β subunits that functions as a master regulator of oxygen homeostasis. Oxygen …

Hypoxia-inducible factor-1 (HIF-1), the master regulator of transcriptional responses to
reduced oxygen tension (hypoxia) in mammalian cells, consists of one HIF-1α and one HIF …

Abstract Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of
transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is …

Oxygen-dependent proteolysis is the primary means of regulating the hypoxia-inducible
factor (HIF) family of transcription factors. The alpha-subunit of HIF factor 1 (HIF-1) contains …

Many molecular and physiological responses to hypoxia in mammals are controlled by the
transcription factors Hypoxia-Inducible Factor-1α (HIF-1α) and HIF-2α. Their ability to …

Abstract Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding
proteins that mediate adaptive responses to reduced oxygen availability. The HIF-1β subunit …