Persistent nuclear actin filaments inhibit transcription by RNA polymerase II

LA Serebryannyy, M Parilla, P Annibale… - Journal of cell …, 2016 - journals.biologists.com
Actin is abundant in the nucleus and it is clear that nuclear actin has important functions.
However, mystery surrounds the absence of classical actin filaments in the nucleus. To …

Structural biochemistry of nuclear actin‐related proteins 4 and 8 reveals their interaction with actin

S Fenn, D Breitsprecher, CB Gerhold, G Witte… - The EMBO …, 2011 - embopress.org
Nuclear actin and actin‐related proteins (Arps) are integral components of various chromatin‐
remodelling complexes. Actin in such nuclear assemblies does not form filaments but …

Nuclear actin: to polymerize or not to polymerize

WA Hofmann, P De Lanerolle - The Journal of cell biology, 2006 - rupress.org
The form and function of actin in the nucleus have been enigmatic for over 30 years.
Recently actin has been assigned numerous functional roles in the nucleus, but its form …

Nucleoplasmic β-actin exists in a dynamic equilibrium between low-mobility polymeric species and rapidly diffusing populations

D McDonald, G Carrero, C Andrin, G de Vries… - The Journal of cell …, 2006 - rupress.org
β-Actin, once thought to be an exclusively cytoplasmic protein, is now known to have
important functions within the nucleus. Nuclear β-actin associates with and functions in …

Conformation-specific antibodies reveal distinct actin structures in the nucleus and the cytoplasm

CA Schoenenberger, S Buchmeier, M Boerries… - Journal of structural …, 2005 - Elsevier
For many years the existence of actin in the nucleus has been doubted because of the lack
of phalloidin staining as well as the failure to document nuclear actin filaments by electron …

Linking actin dynamics and gene transcription to drive cellular motile functions

EN Olson, A Nordheim - Nature reviews Molecular cell biology, 2010 - nature.com
Numerous physiological and pathological stimuli promote the rearrangement of the actin
cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively …

[HTML][HTML] Regulation of actin cytoskeleton dynamics in cells

SH Lee, R Dominguez - Molecules and cells, 2010 - Elsevier
The dynamic remolding of the actin cytoskeleton is a critical part of most cellular activities,
and malfunction of cytoskeletal proteins results in various human diseases. The transition …

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing

T Viita, S Kyheröinen, B Prajapati… - Journal of cell …, 2019 - journals.biologists.com
In addition to its essential functions within the cytoskeleton, actin also localizes to the cell
nucleus, where it is linked to many important nuclear processes from gene expression to …

The Nuclear Actin-related Protein of Saccharomyces cerevisiae, Act3p/Arp4, Interacts with Core Histones

M Harata, Y Oma, S Mizuno, YW Jiang… - Molecular biology of …, 1999 - Am Soc Cell Biol
Act3p/Arp4, an essential actin-related protein of Saccharomyces cerevisiae located within
the nucleus, is, according to genetic data, involved in transcriptional regulation. In addition to …

Mutant actins that stabilise F‐actin use distinct mechanisms to activate the SRF coactivator MAL

G Posern, F Miralles, S Guettler, R Treisman - The EMBO journal, 2004 - embopress.org
Nuclear accumulation of the serum response factor coactivator MAL/MKL1 is controlled by
its interaction with G‐actin, which results in its retention in the cytoplasm in cells with low …